Three-dimensional distribution of ST-T wave alternans during acute ischemia

Introduction: A canine model of reversible ischemia was used to measure the magnitude and transmural distribution of repolarization alternans, Methods and Results: Twenty-four multielectrode needles were inserted into a reversibly ischemic region created by 8 minutes of coronary occlusion, One hundred ninety-two unipolar electrograms were simultaneously recorded at 1-minute intervals for 8 minutes of ischemia and 3 minutes of reflow recovery, Beat-to-beat repolarization alternans was quantified for all electrograms using the standard deviation of QRST integrals, When alternans from animals that fibrillated was compared with alternans from animals that did not, the magnitude of alternans in the fibrillation group was an average standard deviation of 1125 +/- 99.7 mV-msec at the time of fibrillation and 409 +/- 183 mV-msec at 8 minutes of ischemia in the animals that did not fibrillate, The increase in alternans occurred mainly in the mid-myocardial and epicardial regions in the animals that fibrillated. QRS morphology of sequential electrograms did not differ in beat-to-beat comparison, suggesting that repolarization alternans measured was not due to alternating conduction block in the region of reversible ischemia, Conclusion: During acute ischemia, the magnitude and distribution of repolarization alternans are greater and differ in hearts that experience ventricular fibrillation, This observation may have clinical utility in arrhythmia prediction, It also is consistent with the possibility there may be multiple mechanisms for repolarization alternans.