Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys

被引：41

作者：

Abbink, Peter ^{[1
]}

Larocca, Rafael A. ^{[1
]}

Dejnirattisai, Wanwisa ^{[2
]}

Peterson, Rebecca ^{[1
]}

Nkolola, Joseph P. ^{[1
]}

Borducchi, Erica N. ^{[1
]}

Supasa, Piyada ^{[2
]}

Mongkolsapaya, Juthathip ^{[2
,3
]}

Screaton, Gavin R. ^{[4
]}

Barouch, Dan H. ^{[1
,5
]}

机构：

[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02115 USA

[2] Imperial Coll, Div Immunol & Inflammat, Dept Med, Hammersmith Campus, London, England

[3] Mahidol Univ, Fac Med, Dengue Hemorrhag Fever Res Unit, Off Res & Dev,Siriraj Hosp, Bangkok, Thailand

[4] Univ Oxford, John Radcliffe Hosp, Dept Med, Oxford, England

[5] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA

来源：

NATURE MEDICINE | 2018年 / 24卷 / 06期

基金：

美国国家卫生研究院;

关键词：

VIRUS-INFECTION; CROSS-REACTIVITY; VACCINE; POTENT; ENHANCEMENT; CHALLENGE;

D O I：

10.1038/s41591-018-0056-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV)-endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potently cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV.

引用

页码：721 / +

页数：4

共 20 条

[1] Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys [J].

Abbink, Peter ;

Larocca, Rafael A. ;

De La Barrera, Rafael A. ;

Bricault, Christine A. ;

Moseley, Edward T. ;

Boyd, Michael ;

Kirilova, Marinela ;

Li, Zhenfeng ;

Ng'ang'a, David ;

Nanayakkara, Ovini ;

Nityanandam, Ramya ;

Mercado, Noe B. ;

Borducchi, Erica N. ;

Agarwal, Arshi ;

Brinkman, Amanda L. ;

Cabral, Crystal ;

Chandrashekar, Abishek ;

Giglio, Patricia B. ;

Jetton, David ;

Jimenez, Jessica ;

Lee, Benjamin C. ;

Mojta, Shanell ;

Molloy, Katherine ;

Shetty, Mayuri ;

Neubauer, George H. ;

Stephenson, Kathryn E. ;

Peron, Jean Pierre S. ;

Zanotto, Paolo M. de A. ;

Misamore, Johnathan ;

Finneyfrock, Brad ;

Lewis, Mark G. ;

Alter, Galit ;

Modjarrad, Kayvon ;

Jarman, Richard G. ;

Eckels, Kenneth H. ;

Michael, Nelson L. ;

Thomas, Stephen J. ;

Barouch, Dan H. .

SCIENCE, 2016, 353 (6304) :1129-1132

[2] Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys [J].

Aid, Malika ;

Abbink, Peter ;

Larocca, Rafael A. ;

Boyd, Michael ;

Nityanandam, Ramya ;

Nanayakkara, Ovini ;

Martinot, Amanda J. ;

Moseley, Edward T. ;

Blass, Eryn ;

Borducchi, Erica N. ;

Chandrashekar, Abishek ;

Brinkman, Amanda L. ;

Molloy, Katherine ;

Jetton, David ;

Tartaglia, Lawrence J. ;

Liu, Jinyan ;

Best, Katharine ;

Perelson, Alan S. ;

De la Barrera, Rafael A. ;

Lewis, Mark G. ;

Barouch, Dan H. .

CELL, 2017, 169 (04) :610-620

[3] Structural basis of potent Zika-dengue virus antibody cross-neutralization [J].

Barba-Spaeth, Giovanna ;

Dejnirattisai, Wanwisa ;

Rouvinski, Alexander ;

Vaney, Marie-Christine ;

Medits, Iris ;

Sharma, Arvind ;

Simon-Loriere, Etienne ;

Sakuntabhai, Anavaj ;

Cao-Lormeau, Van-Mai ;

Haouz, Ahmed ;

England, Patrick ;

Stiasny, Karin ;

Mongkolsapaya, Juthathip ;

Heinz, Franz X. ;

Screaton, Gavin R. ;

Rey, Felix A. .

NATURE, 2016, 536 (7614) :48-+

[4] Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity [J].

Bardina, Susana V. ;

Bunduc, Paul ;

Tripathi, Shashank ;

Duehr, James ;

Frere, Justin J. ;

Brown, Julia A. ;

Nachbagauer, Raffael ;

Foster, Gregory A. ;

Krysztof, David ;

Tortorella, Domenico ;

Stramer, Susan L. ;

Garcia-Sastre, Adolfo ;

Krammer, Florian ;

Lim, Jean K. .

SCIENCE, 2017, 356 (6334) :175-180

[5] Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys [J].

Barouch, Dan H. ;

Whitney, James B. ;

Moldt, Brian ;

Klein, Florian ;

Oliveira, Thiago Y. ;

Liu, Jinyan ;

Stephenson, Kathryn E. ;

Chang, Hui-Wen ;

Shekhar, Karthik ;

Gupta, Sanjana ;

Nkolola, Joseph P. ;

Seaman, Michael S. ;

Smith, Kaitlin M. ;

Borducchi, Erica N. ;

Cabral, Crystal ;

Smith, Jeffrey Y. ;

Blackmore, Stephen ;

Sanisetty, Srisowmya ;

Perry, James R. ;

Beck, Matthew ;

Lewis, Mark G. ;

Rinaldi, William ;

Chakraborty, Arup K. ;

Poignard, Pascal ;

Nussenzweig, Michel C. ;

Burton, Dennis R. .

NATURE, 2013, 503 (7475) :224-+

[6] Guillain-Barre syndrome associated with Zika virus infection [J].

Brasil, Patricia ;

Sequeira, Patricia Carvalho ;

Freitas, Andrea D'Avila ;

Zogbi, Heruza Einsfeld ;

Calvet, Guilherme Amaral ;

de Souza, Rogerio Valls ;

Siqueira, Andre Machado ;

Lima de Mendonca, Marcos Cesar ;

Ribeiro Nogueira, Rita Maria ;

Bispo de Filippis, Ana Maria ;

Solomon, Tom .

LANCET, 2016, 387 (10026) :1482-1482

[7] Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus [J].

Dejnirattisai, Wanwisa ;

Supasa, Piyada ;

Wongwiwat, Wiyada ;

Rouvinski, Alexander ;

Barba-Spaeth, Giovanna ;

Duangchinda, Thaneeya ;

Sakuntabhai, Anavaj ;

Cao-Lormeau, Van-Mai ;

Malasit, Prida ;

Rey, Felix A. ;

Mongkolsapaya, Juthathip ;

Screaton, Gavin R. .

NATURE IMMUNOLOGY, 2016, 17 (09) :1102-1108

[8] A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus [J].

Dejnirattisai, Wanwisa ;

Wongwiwat, Wiyada ;

Supasa, Sunpetchuda ;

Zhang, Xiaokang ;

Dai, Xinghong ;

Rouvinsky, Alexander ;

Jumnainsong, Amonrat ;

Edwards, Carolyn ;

Nguyen Than Ha Quyen ;

Duangchinda, Thaneeya ;

Grimes, Jonathan M. ;

Tsai, Wen-Yang ;

Lai, Chih-Yun ;

Wang, Wei-Kung ;

Malasit, Prida ;

Farrar, Jeremy ;

Simmons, Cameron P. ;

Zhou, Z. Hong ;

Rey, Felix A. ;

Mongkolsapaya, Juthathip ;

Screaton, Gavin R. .

NATURE IMMUNOLOGY, 2015, 16 (02) :170-+

[9] Rapid development of a DNA vaccine for Zika virus [J].

Dowd, Kimberly A. ;

Ko, Sung-Youl ;

Morabito, Kaitlyn M. ;

Yang, Eun Sung ;

Pelc, Rebecca S. ;

DeMaso, Christina R. ;

Castilho, Leda R. ;

Abbink, Peter ;

Boyd, Michael ;

Nityanandam, Ramya ;

Gordon, David N. ;

Gallagher, John Robert ;

Chen, Xuejun ;

Todd, John-Paul ;

Tsybovsky, Yaroslav ;

Harris, Audray ;

Huang, Yan-Jang S. ;

Higgs, Stephen ;

Vanlandingham, Dana L. ;

Andersen, Hanne ;

Lewis, Mark G. ;

De La Barrera, Rafael ;

Eckels, Kenneth H. ;

Jarman, Richard G. ;

Nason, Martha C. ;

Barouch, Dan H. ;

Roederer, Mario ;

Kong, Wing-Pui ;

Mascola, John R. ;

Pierson, Theodore C. ;

Graham, Barney S. .

SCIENCE, 2016, 354 (6309) :237-240

[10] Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection [J].

Fernandez, Estefania ;

Dejnirattisai, Wanwisa ;

Cao, Bin ;

Scheaffer, Suzanne M. ;

Supasa, Piyada ;

Wongwiwat, Wiyada ;

Esakky, Prabagaran ;

Drury, Andrea ;

Mongkolsapaya, Juthathip ;

Moley, Kelle H. ;

Mysorekar, Indira U. ;

Screaton, Gavin R. ;

Diamond, Michael S. .

NATURE IMMUNOLOGY, 2017, 18 (11) :1261-+

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