Predictors of Survival in Stage IV Metastatic Colorectal Cancer

被引：9

作者：

Zacharakis, Michalis ^{[1
]}

Xynos, Ioannis D. ^{[2
]}

Lazaris, Andreas ^{[3
]}

Smaro, Tsaousi ^{[3
]}

Kosmas, Christos ^{[6
]}

Dokou, Anna ^{[2
]}

Felekouras, Evangelos ^{[1
]}

Antoniou, Efstathios ^{[4
]}

Polyzos, Aris ^{[5
]}

Sarantonis, John ^{[2
]}

Syrios, John ^{[3
]}

Zografos, George ^{[7
]}

Papalambros, Alexandros ^{[1
]}

Tsavaris, Nikolas ^{[2
]}

机构：

[1] Univ Athens, Sch Med, Laikon Gen Hosp, Dept Surg 1, GR-11527 Athens, Greece

[2] Univ Athens, Sch Med, Laikon Gen Hosp, Dept Pathophysiol,Oncol Unit, GR-11527 Athens, Greece

[3] Univ Athens, Sch Med, Laikon Gen Hosp, Dept Pathol 1, GR-11527 Athens, Greece

[4] Univ Athens, Sch Med, Laikon Gen Hosp, Dept Surg Propedeut 2, GR-11527 Athens, Greece

[5] Univ Athens, Sch Med, Laikon Gen Hosp, Oncol Unit,Dept Internal Med 1, GR-11527 Athens, Greece

[6] Metaxa Canc Hosp, Dept Med Oncol 2, Piraeus, Greece

[7] G Gennimatas Gen Hosp, Dept Surg, Athens, Greece

来源：

ANTICANCER RESEARCH | 2010年 / 30卷 / 02期

关键词：

Prognostic factors; colorectal cancer; chemotherapy; survival; PROGNOSTIC-FACTORS; MULTIVARIATE-ANALYSIS; TUMOR RECURRENCE; ELDERLY-PATIENTS; CARCINOMA; IRINOTECAN; CHEMOTHERAPY; DETERMINANTS; MANAGEMENT; PROTEIN;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of this study was to evaluate predictors of survival in stage IV metastatic colorectal cancer (CRC). Patients and Methods: A total of 541 patients with histologically proven metastatic CRC (UICC stage IV) were retrospectively analysed and 37 variables were tested for their potential relationship to survival. Results: Mean survival time was recorded at 12.8 months [95% confidence interval (CI) 12.0-13.5]. Three factors were independently associated with improved survival: combination chemotherapy, improved performance status and dermatological complications. Eight factors were independently associated with unfavorable survival: worsened performance status, C-reactive protein >5 mg/dl, anemia, anorexia, weight loss >= 10%, fatigue hypoalbuminemia and blood transfusions. Conclusion: A number of factors could be used as predictors of survival in patients with stage IV metastatic CRC. Patients who are relatively fit, have low CRP levels and tolerate combination chemotherapy appear to have a more favorable survival outcome.

引用

页码：653 / 660

页数：8

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