PARP inhibitors: the race is on

被引:121
作者
Brown, Jessica S. [1 ,2 ]
Kaye, Stan B. [1 ,2 ]
Yap, Timothy A. [1 ,2 ]
机构
[1] Royal Marsden Hosp, Drug Dev Unit, London SW3 6JJ, England
[2] Inst Canc Res, Div Clin Studies, London SW3 6JB, England
关键词
BRCA MUTATION CARRIERS; POLY(ADP-RIBOSE) POLYMERASE; OVARIAN-CANCER; OPEN-LABEL; OLAPARIB; MULTICENTER; STRATEGY; PHASE-2; TUMORS; TRIAL;
D O I
10.1038/bjc.2016.67
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:713 / 715
页数:3
相关论文
共 22 条
[1]   Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase [J].
Bryant, HE ;
Schultz, N ;
Thomas, HD ;
Parker, KM ;
Flower, D ;
Lopez, E ;
Kyle, S ;
Meuth, M ;
Curtin, NJ ;
Helleday, T .
NATURE, 2005, 434 (7035) :913-917
[2]  
Drew Y, 2016, BR J CANC IN PRESS
[3]   Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy [J].
Farmer, H ;
McCabe, N ;
Lord, CJ ;
Tutt, ANJ ;
Johnson, DA ;
Richardson, TB ;
Santarosa, M ;
Dillon, KJ ;
Hickson, I ;
Knights, C ;
Martin, NMB ;
Jackson, SP ;
Smith, GCM ;
Ashworth, A .
NATURE, 2005, 434 (7035) :917-921
[4]   Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses in BRCA Carrier Ovarian Cancer Correlating With Platinum-Free Interval [J].
Fong, Peter C. ;
Yap, Timothy A. ;
Boss, David S. ;
Carden, Craig P. ;
Mergui-Roelvink, Marja ;
Gourley, Charlie ;
De Greve, Jacques ;
Lubinski, Jan ;
Shanley, Susan ;
Messiou, Christina ;
A'Hern, Roger ;
Tutt, Andrew ;
Ashworth, Alan ;
Stone, John ;
Carmichael, James ;
Schellens, Jan H. M. ;
de Bono, Johann S. ;
Kaye, Stan B. .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15) :2512-2519
[5]   Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers. [J].
Fong, Peter C. ;
Boss, David S. ;
Yap, Timothy A. ;
Tutt, Andrew ;
Wu, Peijun ;
Mergui-Roelvink, Marja ;
Mortimer, Peter ;
Swaisland, Helen ;
Lau, Alan ;
O'Connor, Mark J. ;
Ashworth, Alan ;
Carmichael, James ;
Kaye, Stan B. ;
Schellens, Jan H. M. ;
de Bono, Johann S. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (02) :123-134
[6]   Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study [J].
Gelmon, Karen A. ;
Tischkowitz, Marc ;
Mackay, Helen ;
Swenerton, Kenneth ;
Robidoux, Andre ;
Tonkin, Katia ;
Hirte, Hal ;
Huntsman, David ;
Clemons, Mark ;
Gilks, Blake ;
Yerushalmi, Rinat ;
Macpherson, Euan ;
Carmichael, James ;
Oza, Amit .
LANCET ONCOLOGY, 2011, 12 (09) :852-861
[7]   The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings [J].
Helleday, Thomas .
MOLECULAR ONCOLOGY, 2011, 5 (04) :387-393
[8]   Olaparib Monotherapy in Patients With Advanced Cancer and a Germline BRCA1/2 Mutation [J].
Kaufman, Bella ;
Shapira-Frommer, Ronnie ;
Schmutzler, Rita K. ;
Audeh, M. William ;
Friedlander, Michael ;
Balmana, Judith ;
Mitchell, Gillian ;
Fried, Georgeta ;
Stemmer, Salomon M. ;
Hubert, Ayala ;
Rosengarten, Ora ;
Steiner, Mariana ;
Loman, Niklas ;
Bowen, Karin ;
Fielding, Anitra ;
Domchek, Susan M. .
JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (03) :244-250
[9]   Phase II, Open-Label, Randomized, Multicenter Study Comparing the Efficacy and Safety of Olaparib, a Poly (ADP-Ribose) Polymerase Inhibitor, and Pegylated Liposomal Doxorubicin in Patients With BRCA1 or BRCA2 Mutations and Recurrent Ovarian Cancer [J].
Kaye, Stan B. ;
Lubinski, Jan ;
Matulonis, Ursula ;
Ang, Joo Ern ;
Gourley, Charlie ;
Karlan, Beth Y. ;
Amnon, Amit ;
Bell-McGuinn, Katherine M. ;
Chen, Lee-May ;
Friedlander, Michael ;
Safra, Tamar ;
Vergote, Ignace ;
Wickens, Mark ;
Lowe, Elizabeth S. ;
Carmichael, James ;
Kaufman, Bella .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (04) :372-379
[10]   Gene Expression Profile of BRCAness That Correlates With Responsiveness to Chemotherapy and With Outcome in Patients With Epithelial Ovarian Cancer [J].
Konstantinopoulos, Panagiotis A. ;
Spentzos, Dimitrios ;
Karlan, Beth Y. ;
Taniguchi, Toshiyasu ;
Fountzilas, Elena ;
Francoeur, Nancy ;
Levine, Douglas A. ;
Cannistra, Stephen A. .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (22) :3555-3561