Novel folated Pluronic/poly(lactic acid) nanoparticles for targeted delivery of paclitaxel

被引：13
作者：
Xiong, Xiang Yuan [1 ]
Tao, Long [1 ]
Qin, Xiang [1 ]
Li, Zi Ling [1 ]
Gong, Yan Chun [1 ]
Li, Yu Ping [1 ]
Yang, Yi Jia [1 ]
Liu, Zhi Yong [2 ]
机构：
[1] Jiangxi Sci & Technol Normal Univ, Sch Life Sci, Nanchang 330013, Peoples R China
[2] Jiangxi Univ Tradit Chinese Med, Lab Anim Sci & Technol Ctr, Nanchang 330045, Peoples R China
来源：
RSC ADVANCES | 2016年 / 6卷 / 58期
基金：
中国国家自然科学基金;
关键词：
VITAMIN-E TPGS; IN-VITRO; DRUG-DELIVERY; ANTICANCER DRUGS; COPOLYMER MICELLES; TUMOR ACCUMULATION; CONTROLLED-RELEASE; POLYMERIC MICELLE; BLOCK-COPOLYMER; BREAST-CANCER;
D O I：
10.1039/c6ra09271c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The purpose of this study was to explore the in vitro and in vivo targeting behaviors of novel folated Pluronic/poly(lactic acid) block copolymers (FA-Pluronic-PLA) for the anticancer drug, paclitaxel. Both paclitaxel-loaded FA-Pluronic-PLA nanoparticles show in vitro sustained release and in vivo prolonged circulation time. The in vitro actively targeting behavior of paclitaxel-loaded FA-Pluronic-PLA nanoparticles against OVCAR-3 cells (folate receptor positive) was proved by the cytotoxicity tests. The in vivo targeting properties of nanoparticles were also studied in OVCAR-3 ovarian tumor-bearing mice. It was observed that the tumor growth percentage for targeted paclitaxel-loaded FA-F127-PLA nanoparticles is lower than that for non-targeted paclitaxel-loaded PLA-F127-PLA nanoparticles. It was observed from FM images that FA-Pluronic-PLA nanoparticles are mainly localized within the cytoplasm of OVCAR-3 cells.
引用
收藏
页码：52729 / 52738
页数：10
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