Interactions of Amyloid-β with Membrane Proteins

被引：28

作者：

Wiatrak, Benita ^{[1
,2
]}

Piasny, Janusz ^{[1
]}

Kuzniarski, Amadeusz ^{[3
]}

Gasiorowski, Kazimierz ^{[2
]}

机构：

[1] Wroclaw Med Univ, Dept Pharmacol, Mikulicza Radeckiego 2, PL-50345 Wroclaw, Poland

[2] Wroclaw Med Univ, Dept Basic Med Sci, Borowska 211, PL-50556 Wroclaw, Poland

[3] Wroclaw Med Univ, Dept Prosthet Dent, Krakowska 26, PL-50425 Wroclaw, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 11期

关键词：

Alzheimer's disease; amyloid-beta; NMDA receptor; PrPC protein; Fyn kinase; A-BETA; ALZHEIMERS-DISEASE; A-BETA(1-40) PEPTIDE; PRECURSOR PROTEIN; AGGREGATION; TAU; NEUROTOXICITY; OLIGOMERS; CLEAVAGE; RESIDUE;

D O I：

10.3390/ijms22116075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In developing and developed countries, an increasing elderly population is observed. This affects the growing percentage of people struggling with neurodegenerative diseases, including Alzheimer's disease. Nevertheless, the pathomechanism of this disease is still unknown. This contributes to problems with early diagnosis of the disease as well as with treatment. One of the most popular hypotheses of Alzheimer's disease is related to the pathological deposition of amyloid-beta (A beta) in the brain of ill people. In this paper, we discuss issues related to A beta and its relationship in the development of Alzheimer's disease. The structure of A beta and its interaction with the cell membrane are discussed. Not only do the extracellular plaques affect nerve cells, but other forms of this peptide as well.

引用

页数：14

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