DNA mismatch repair protein immunohistochemistry - an illustrated guide

被引：16

作者：

Bateman, Adrian C. ^{[1
]}

机构：

[1] Univ Hosp Southampton NHS Fdn Trust, Dept Cellular Pathol, Southampton, Hants, England

来源：

HISTOPATHOLOGY | 2021年 / 79卷 / 02期

关键词：

immunohistochemistry; cancer; DNA; mismatch repair;

D O I：

10.1111/his.14367

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA mismatch repair (MMR) is an essential physiological process for correcting mutations occurring during DNA replication. Deficient MMR (dMMR) leads to increased tumour mutational burden, with a heightened risk of neoplasia. Demonstration of dMMR via the immunohistochemical assessment of MMR proteins is useful when screening for inherited cancer syndromes (especially Lynch syndrome) and for the prediction of clinical cancer response to conventional chemotherapy and novel immunotherapies. Identification of dMMR may also be helpful in other situations e.g. when considering a diagnosis of conventional dysplasia in sessile serrated lesions of the large intestine. This article provides a practical illustrated guide to DNA MMR interpretation, using a series of clinical examples.

引用

页码：128 / 138

页数：11

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