A plant-like biosynthesis of benzoyl-CoA in the marine bacterium 'Streptomyces maritimus'

被引：52
|
作者：
Hertweck, C
Moore, BS [1 ]
机构：
[1] Univ Arizona, Coll Pharm, Div Med Chem, Tucson, AZ 85721 USA
[2] Univ Washington, Dept Chem, Seattle, WA 98195 USA
来源：
TETRAHEDRON | 2000年 / 56卷 / 46期
基金：
美国国家卫生研究院; 美国海洋和大气管理局;
关键词：
benzoic acid; biosynthesis; phenylalanine ammonia lyase; polyketide; synthase; Streptomyces;
D O I：
10.1016/S0040-4020(00)00765-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first plant-like biosynthesis of benzoic acid in a prokaryote, the marine actinomycete 'Streptomyces maritimus', has been characterized. Feeding experiments with H-2- and C-13-labeled intermediates revealed that phenylalanine is metabolized to benzoyl-coenzyme A (CoA) by means of a phenylalanine ammonia lyase and subsequent beta -oxidation of cinnamoyl-CoA. Benzoyl-CoA serves as the rare starter unit of a type II polyketide synthase producing the structurally novel bacteriostatic polyketides enterocin and the wailupemycins. The results from the feeding study are consistent with the proposed biosynthetic model deduced from the cloned enterocin biosynthesis gene cluster. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：9115 / 9120
页数：6
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