Iridium-catalyzed asymmetric [3+2] annulation of aromatic ketimines with alkynes via C-H activation: unexpected inversion of the enantioselectivity induced by protic acids

被引：58

作者：

Nagamoto, Midori ^{[1
]}

Yamauchi, Daisuke ^{[1
]}

Nishimura, Takahiro ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 34期

关键词：

N-SULFONYL KETIMINES; BOND ACTIVATION; KETONES; EFFICIENT; FUNCTIONALIZATION; CYCLIZATION; 1,3-DIENES; IMINES; CARBOCYCLIZATION; HYDROGENATION;

D O I：

10.1039/c6cc01398h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A cationic iridium/binap catalyst enabled the asymmetric [3+2] annulation of cyclic N-acyl ketimines with internal alkynes via C-H activation to give spiroaminoindene derivatives with high enantioselectivity. The stereochemical course of this annulation was switchable by acid additives.

引用

页码：5876 / 5879

页数：4

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