Primary investigation of 31 infants with suspected congenital rubella syndrome in Sudan

被引：14
作者：
Adam, O. [2 ]
El Hussein, A. [3 ]
El Eragi, A. [4 ]
Jin, L. [1 ]
机构：
[1] Hlth Protect Agcy, Ctr Infect, Virus Reference Dept, London NW9 5EQ, England
[2] Minist Sci & Technol, Natl Res Ctr, Commiss Biotechnol & Genet Engn, Khartoum, Sudan
[3] Minist Sci & Technol, Cent Lab, Khartoum, Sudan
[4] Cent Vet Res Labs, Khartoum, Sudan
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2010年 / 16卷 / 06期
关键词：
Congenital rubella syndrome; genotyping; rubella virus; Sudan; virus isolation; RT-PCR ASSAY; ORAL FLUID; MEASLES; DIAGNOSIS; VIRUS; SURVEILLANCE;
D O I：
10.1111/j.1469-0691.2009.02966.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Between 2005 and 2006, clinical specimens were collected from 31 infants with suspected congenital rubella syndrome (CRS) who presented at six hospitals in Khartoum, Sudan. Eleven (35.5%) were laboratory confirmed as CRS cases by testing for anti-rubella IgM, IgG and viral genome. For the first time in Sudan, the rubella virus genome was directly detected in clinical specimens of six CRS cases and two viruses were isolated in cell culture. Phylogenetic analysis suggested that three genotypes of rubella virus (RV; 1E, 2B and 1G) were co-circulating in Sudan. The study introduced the methodology for CRS confirmation and surveillance in Sudan and provides preliminary data.
引用
收藏
页码：678 / 682
页数：6
相关论文
共 17 条
[1]  
[Anonymous], 2005, Wkly Epidemiol Rec, V80, P125
[2]  
[Anonymous], [No title captured]
[3]  
Best JM, 2007, PERSP MED V, V15, P39, DOI 10.1016/S0168-7069(06)15003-X
[4]   SALIVARY DIAGNOSIS OF MEASLES - A STUDY OF NOTIFIED CASES IN THE UNITED-KINGDOM, 1991-3 [J].
BROWN, DWG ;
RAMSAY, MEB ;
RICHARDS, AF ;
MILLER, E .
BRITISH MEDICAL JOURNAL, 1994, 308 (6935) :1015-1017
[5]   Phylogenetic analysis of rubella viruses found in Morocco, Uganda, Cote d'Ivoire and South Africa from 2001 to 2007 [J].
Caidi, Hayat ;
Abernathy, Emily S. ;
Benjouad, Aziz ;
Smit, Sheilagh ;
Bwogi, Josephine ;
Nanyunja, Miriam ;
El Aouad, Rajae ;
Icenogle, Joseph .
JOURNAL OF CLINICAL VIROLOGY, 2008, 42 (01) :86-90
[6]   Improved RT-PCR for diagnosis and epidemiological surveillance of rubella [J].
Cooray, S ;
Warrener, L ;
Jin, L .
JOURNAL OF CLINICAL VIROLOGY, 2006, 35 (01) :73-80
[7]  
ELBUSHI AM, 1997, THESIS U KHARTOUM KH
[8]   Measles in suburban Khartoum: an epidemiological and clinical study [J].
Ibrahim, SA ;
Mustafa, OM ;
Mukhtar, MM ;
Saleh, EA ;
El Mubarak, HS ;
Abdallah, A ;
El-Hassan, AM ;
Osterhaus, ADME ;
Groen, J ;
de Swart, RL ;
Zijlstra, EE .
TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2002, 7 (05) :442-449
[9]  
Jin L, 2002, B WORLD HEALTH ORGAN, V80, P76
[10]   Development of a dual target-PCR for detection and characterization of measles virus in clinical specimens [J].
Jin, L ;
Richards, A ;
Brown, DWG .
MOLECULAR AND CELLULAR PROBES, 1996, 10 (03) :191-200
12