Asthma with Fixed Airflow Obstruction: From Fixed to Personalized Approach

被引:11
|
作者
Bakakos, Agamemnon [1 ]
Vogli, Stamatina [2 ]
Dimakou, Katerina [2 ]
Hillas, Georgios [2 ]
机构
[1] Natl & Kapodistrian Univ Athens, Univ Dept Resp Med 1, Athens 11527, Greece
[2] Sotiria Chest Dis Hosp, Pulm Dept 5, Athens 11527, Greece
来源
JOURNAL OF PERSONALIZED MEDICINE | 2022年 / 12卷 / 03期
关键词
asthma; fixed obstruction; personalized medicine; ACO; FAO; LUNG-FUNCTION; DOUBLE-BLIND; CLUSTER-ANALYSIS; RISK-FACTORS; INFLAMMATION; LIMITATION; ADULTS; COPD; MEPOLIZUMAB; PHENOTYPES;
D O I
10.3390/jpm12030333
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Asthma is generally characterized by variable symptoms such as dyspnea and wheezing and variable airflow obstruction. This review focuses on a subset of patients suffering from asthma with persistent airflow limitation that is not fully reversible (asthma with fixed airflow obstruction, FAO). The pathophysiology, the risk factors and the clinical outcomes associated with FAO are presented, as well as the distinct clinical entity of severe asthma and its inflammatory subtypes (T2 and non-T2). The current strategies for the treatment of these endotypes and treatment of the distinct Asthma/COPD overlap (ACO) phenotype are described. Management and medical interventions in FAO and/or ACO patients demand a holistic approach, which is not yet clearly established in guidelines worldwide. Finally, a treatment algorithm that includes FAO/ACO management based on pharmacological and non-pharmacological treatment, guideline-based management for specific co-morbidities, and modification of the risk factors is proposed.
引用
收藏
页数:15
相关论文
共 50 条
  • [1] Modern understanding of bronchial asthma with fixed airflow obstruction
    Kraposhina, Angelina Yu
    Sobko, Elena A.
    Demko, Irina, V
    Kacer, Anna B.
    Kazmerchuk, Olga, V
    Abramov, Yuriy, I
    TERAPEVTICHESKII ARKHIV, 2021, 93 (03) : 337 - 342
  • [2] Fixed Airflow Obstruction in Asthma: A Problem of the Whole Lung Not of Just the Airways
    Rutting, Sandra
    Thamrin, Cindy
    Cross, Troy J.
    King, Gregory G.
    Tonga, Katrina O.
    FRONTIERS IN PHYSIOLOGY, 2022, 13
  • [3] Reduced lung elastic recoil and fixed airflow obstruction in asthma
    Tonga, Katrina O.
    Chapman, David G.
    Farah, Claude S.
    Oliver, Brian G.
    Zimmermann, Sabine C.
    Milne, Stephen
    Sanai, Farid
    Jetmalani, Kanika
    Berend, Norbert
    Thamrin, Cindy
    King, Gregory G.
    RESPIROLOGY, 2020, 25 (06) : 613 - 619
  • [4] Fixed Airflow Obstruction among Nonsmokers with Asthma: A Case-Comparison Study
    Sexton, Paul
    Black, Peter
    Wu, Lian
    Sommerville, Fay
    Hamed, Maye
    Metcalf, Patricia
    Kolbe, John
    JOURNAL OF ASTHMA, 2013, 50 (06) : 606 - 612
  • [5] Fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease: 5-year follow-up
    Contoli, Marco
    Baraldo, Simonetta
    Marku, Brunilda
    Casolari, Paolo
    Marwick, John A.
    Turato, Graziella
    Romagnoli, Micaela
    Caramori, Gaetano
    Saetta, Marina
    Fabbri, Leonardo M.
    Papi, Alberto
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (04) : 830 - 837
  • [6] Toward explaining fixed airflow obstruction in asthma
    Rutting, Sandra
    Tonga, Katrina O.
    King, Gregory G.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022, 149 (03) : 890 - 892
  • [7] Asthma and fixed airflow obstruction: Long-term trajectories suggest distinct endotypes
    Smith, Benjamin M.
    Zhao, Nan
    Olivenstein, Ronald
    Lemiere, Catherine
    Hamid, Qutayba
    Martin, James G.
    CLINICAL AND EXPERIMENTAL ALLERGY, 2021, 51 (01): : 39 - 48
  • [8] Inflammatory patterns in fixed airflow obstruction are dependent on the presence of asthma
    Mogensen, Ida
    Jacinto, Tiago
    Alving, Kjell
    Fonseca, Joao A.
    Janson, Christer
    Malinovschi, Andrei
    PLOS ONE, 2020, 15 (12):
  • [9] Fixed airflow obstruction in asthma: a descriptive study of patient profiles and effect on treatment responses
    Tashkin, Donald P.
    Chipps, Bradley E.
    Trudo, Frank
    Zangrilli, James G.
    JOURNAL OF ASTHMA, 2014, 51 (06) : 603 - 609
  • [10] Oscillometry and Asthma Control in Patients With and Without Fixed Airflow Obstruction
    Cottee, Alice M.
    Seccombe, Leigh M.
    Thamrin, Cindy
    King, Gregory G.
    Peters, Matthew J.
    Farah, Claude S.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2022, 10 (05): : 1260 - +