Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography

被引:25
作者
Song, Jun [1 ,2 ]
Swisher, Christine Leon [1 ,3 ]
Im, Hyungsoon [1 ,3 ]
Jeong, Sangmoo [1 ,3 ]
Pathania, Divya [1 ,3 ]
Iwamoto, Yoshiko [1 ]
Pivovarov, Misha [1 ,3 ]
Weissleder, Ralph [1 ,3 ,4 ]
Lee, Hakho [1 ,3 ]
机构
[1] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
[2] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA
[3] Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA
[4] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA USA
来源
SCIENTIFIC REPORTS | 2016年 / 6卷
关键词
ALGORITHMS;
D O I
10.1038/srep24681
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Lens-free digital in-line holography (LDIH) is a promising technology for portable, wide field-of-view imaging. Its resolution, however, is limited by the inherent pixel size of an imaging device. Here we present a new computational approach to achieve sub-pixel resolution for LDIH. The developed method is a sparsity-based reconstruction with the capability to handle the non-linear nature of LDIH. We systematically characterized the algorithm through simulation and LDIH imaging studies. The method achieved the spatial resolution down to one-third of the pixel size, while requiring only single-frame imaging without any hardware modifications. This new approach can be used as a general framework to enhance the resolution in nonlinear holographic systems.
引用
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页数:9
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