Paraneoplastic Anti-3-hydroxy-3-methylglutary-coenzyme A Reductase Antibody-positive Immune-mediated Necrotizing Myopathy in a Patient with Uterine Cancer

被引：5

作者：

Mizuma, Atsushi ^{[1
]}

Kouchi, Maiko ^{[1
]}

Netsu, Shizuka ^{[1
]}

Yutani, Sachiko ^{[1
]}

Kitao, Ruriko ^{[2
]}

Suzuki, Shigeaki ^{[3
]}

Murata, Kenya ^{[4
]}

Nagata, Eiichiro ^{[1
]}

Takizawa, Shunya ^{[1
]}

机构：

[1] Tokai Univ, Dept Neurol, Sch Med, Hiratsuka, Kanagawa, Japan

[2] Natl Hakone Hosp, Dept Neurol, Odawara, Kanagawa, Japan

[3] Keio Univ, Dept Neurol, Sch Med, Tokyo, Japan

[4] Wakayama Med Univ, Dept Neurol, Wakayama, Wakayama, Japan

来源：

INTERNAL MEDICINE | 2017年 / 56卷 / 14期

关键词：

immune-mediated necrotizing myopathy; HMGCR; paraneoplastic syndrome; uterine cancer; steroid therapy; HMG-COA REDUCTASE; STATIN;

D O I：

10.2169/internalmedicine.56.8134

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report the case of a 69-year-old woman with proximal limb muscle weakness, who received postoperative chemotherapy for uterine cancer. Her serum creatinine kinase level was high (10,779 mg/dL) and a muscle biopsy from her left biceps revealed various sizes of muscle fibers accompanied by necrotic and regenerating fibers. She was positive for anti-3 hydroxy-3-methylglutary-coenzyme A reductase (anti-HMGCR) antibodies, but negative for anti-signal recognition particle (anti-SRP) antibodies. She was diagnosed with immune-mediated necrotizing myopathy (IMNM) and treated with prednisolone. Our findings indicate that not only drug-induced myopathy but also paraneoplastic myopathy can be involved in the pathogenesis of IMNM.

引用

页码：1915 / 1918

页数：4

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