α-Viniferin activates autophagic apoptosis and cell death by reducing glucocorticoid receptor expression in castration-resistant prostate cancer cells

被引:15
作者
Cheng, Kejun [1 ]
Liu, Xi [2 ,3 ]
Chen, Lu [2 ]
Lv, Jian-Min [2 ]
Qu, Fa-Jun [3 ]
Pan, Xiu-Wu [3 ]
Li, Lin [3 ]
Cui, Xin-Gang [3 ]
Gao, Yi [2 ]
Xu, Dan-Feng [2 ]
机构
[1] Lishui Inst Agr Sci, Chem Biol Ctr, Lishui 323000, Zhejiang, Peoples R China
[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Urol, Sch Med, Shanghai 200025, Peoples R China
[3] Second Mil Med Univ, Affiliated Hosp 3, Dept Urol, Shanghai 201805, Peoples R China
基金
中国国家自然科学基金;
关键词
alpha-Viniferin; Autophagy; Prostate cancer; Glucocorticoid receptor; AMPK; ANDROGEN; RESVERATROL; HYPOXIA; TRIALS;
D O I
10.1007/s12032-018-1163-y
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Prostate cancer (PCa) is one of the most commonly diagnosed urological malignancies. However, there are limited therapies for PCa patients who develop biochemical recurrence after androgen deprivation therapy (ADT). In the present study, we investigated the therapeutic efficacy and mechanism of alpha-Viniferin (KCV), an oligostilbene of trimeric resveratrol, against human PCa cells and found that it markedly inhibited the proliferation of LNCaP, DU145, and PC-3 cancer cells in a time- and dose-dependent manner, and had a strong cytotoxicity in non-androgen-dependent PCa cells. In addition, KCV inhibited AR downstream expression in LNCaP cells, and inhibited activation of GR signaling pathway in DU145 and PC-3. Further investigation indicated that KCV could induce cancer cell apoptosis through AMPK-mediated activation of autophagy, and inhibited GR expression in castration-resistant prostate cancer(CRPC). These findings suggest that KCV may prove to be a novel and effective therapeutic agent for the treatment of CRPC.
引用
收藏
页数:11
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