Lewis Acid Catalyzed Three-Component [3+2] Cycloaddition Reaction Using Pentafulvene as 2π Component: An Easy Way to Construct Pentaleno(1,2-b)indoles

被引：8
作者：
Santhini, P. V. [1 ,2 ]
Chand, S. Sarath [1 ,2 ]
John, Jubi [1 ,2 ]
Varma, R. Luxmi [1 ,2 ]
Jaroschik, Florian [3 ,4 ]
Radhakrishnan, K. V. [1 ,2 ]
机构：
[1] Natl Inst Interdisciplinary Sci & Technol CSIR, Organ Chem Sect, Trivandrum 695019, Kerala, India
[2] Acad Sci & Innovat Res AcSIR, New Delhi 110001, India
[3] Inst Chim Mol Reims, BP 1039, F-51687 Reims, France
[4] Univ Reims, BP 1039, F-51687 Reims, France
来源：
SYNLETT | 2017年 / 28卷 / 08期
关键词：
fulvene; indole; cycloaddition; multicomponent reaction; cyclopentaleno indoles; DIELS-ALDER REACTION; INDOLE ALKALOIDS; FACILE SYNTHESIS; MULTICOMPONENT REACTIONS; 3-OXIDOPYRYLIUM BETAINE; ORGANIC-SYNTHESIS; NATURAL-PRODUCTS; FULVENES; ACCESS; CYCLIZATION;
D O I：
10.1055/s-0036-1588696
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile route toward the synthesis of pentaleno(1,2-b) in-doles via multicomponent reaction of indole, aldehyde, and pentafulvene is realized. The reaction proceeds through Lewis acid catalyzed [3+2] cycloaddition of in situ generated indolylmethanol and pentafulvene. This methodology provides an easy access to biologically relevant indole derivatives.
引用
收藏
页码：951 / 956
页数：6
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