ent-Kaurane and ent-Pimarane Diterpenoids from Siegesbeckia pubescens

被引:54
作者
Wang, Rui [1 ]
Chen, Wen-Hao [1 ,2 ]
Shi, Yan-Ping [1 ,2 ]
机构
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Province, Lanzhou 730000, Peoples R China
来源
JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 01期
基金
中国国家自然科学基金;
关键词
TERPENOIDS;
D O I
10.1021/np9005579
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Phytochemical investigation of the above-ground parts of Siegesbeckia pubescens yielded 25 diterpenoids, including five new ent-pimarane diterpenoids (1-3, 11, and 12) and four new ent-kaurane diterpenoids (13-16). The structures and relative configurations of the new compounds were elucidated by comprehensive spectroscopic analysis and by comparison of their NMR data with those of related compounds. Single-crystal X-ray diffraction analysis confirmed the structures of 8, 13, and 14. Seven of these diterpenoids were evaluated for cytotoxic activity against HSC-T6, HeLa, and B 16 cell lines. Compounds I I and 14 exhibited moderate cytotoxicity.
引用
收藏
页码:17 / 21
页数:5
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