Fungal glycans and the innate immune recognition

被引：82

作者：

Barreto-Bergter, Eliana ^{[1
]}

Figueiredo, Rodrigo T. ^{[2
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Microbiol, Dept Microbiol Geral, BR-21941902 Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Unidade Xerem, BR-21941902 Rio De Janeiro, Brazil

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2014年 / 4卷

关键词：

fungal pathogens; polysaccharides; glycoconjugates; pattern recognition receptors; innate immunity; C-TYPE LECTIN; MACROPHAGE MANNOSE RECEPTOR; BETA-GLUCAN RECEPTOR; TOLL-LIKE RECEPTORS; CANDIDA-ALBICANS PHOSPHOLIPOMANNAN; O-LINKED OLIGOSACCHARIDES; HUMAN DENDRITIC CELLS; CYSTEINE-RICH DOMAIN; DC-SIGN CD209; ASPERGILLUS-FUMIGATUS;

D O I：

10.3389/fcimb.2014.00145

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Polysaccharides such as alpha- and beta-glucans, chitin, and glycoproteins extensively modified with both N- and O-linked carbohydrates are the major components of fungal surfaces. The fungal cell wall is an excellent target for the action of antifungal agents, since most of its components are absent from mammalian cells. Recognition of these carbohydrate-containing molecules by the innate immune system triggers inflammatory responses and activation of microbicidal mechanisms by leukocytes. This review will discuss the structure of surface fungal glycoconjugates and polysaccharides and their recognition by innate immune receptors.

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页数：17

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