Beneficial mutations and the dynamics of adaptation in asexual populations

被引:139
作者
Sniegowski, Paul D. [1 ]
Gerrish, Philip J. [2 ,3 ]
机构
[1] Univ Penn, Dept Biol, Philadelphia, PA 19063 USA
[2] Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA
[3] Univ Lisbon, Dept Math, Ctr Matemat & Aplicacoes Fundamentais, P-1649003 Lisbon, Portugal
基金
美国国家卫生研究院;
关键词
beneficial mutations; periodic selection; clonal interference; multiple mutations; asexual populations; ESCHERICHIA-COLI POPULATIONS; CLONAL INTERFERENCE; SACCHAROMYCES-CEREVISIAE; PERIODIC SELECTION; EXPERIMENTAL EVOLUTION; REGULATORY MUTATIONS; ARTIFICIAL SELECTION; DIMINISHING RETURNS; BACTERIAL EVOLUTION; ADAPTIVE MUTATIONS;
D O I
10.1098/rstb.2009.0290
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We discuss the dynamics of adaptive evolution in asexual (clonal) populations. The classical 'periodic selection' model of clonal evolution assumed that beneficial mutations are very rare and therefore substitute unfettered into populations as occasional, isolated events. Newer models allow for the possibility that beneficial mutations are sufficiently common to coexist and compete for fixation within populations. Experimental evolution studies in microbes provide empirical support for stochastic models in which both selection and mutation are strong effects and clones compete for fixation; however, the relative importance of competition among clones bearing mutations of different selective effects versus competition among clones bearing multiple mutations remains unresolved. We provide some new theoretical results, moreover, suggesting that population dynamics consistent with the periodic selection model can arise even in a deterministic model that can accommodate a very high beneficial mutation rate.
引用
收藏
页码:1255 / 1263
页数:9
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