Acyl-CoA: Cholesterol acyltransferase inhibitors from Magnolia obovata

被引：31
作者：
Kwon, BM
Kim, MK
Lee, SH
Kim, JA
Lee, IR
Kim, YK
Bok, SH
机构：
[1] KIST, Korea Res Inst Biosci & Biotechnol, Prot Regulatro RU, Taejon 305600, South Korea
[2] Ewha Womans Univ, Coll Pharm, Seoul, South Korea
来源：
PLANTA MEDICA | 1997年 / 63卷 / 06期
关键词：
D O I：
10.1055/s-2006-957762
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
In the course of a search for acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors from natural sources, new types of ACAT inhibitors were isolated from the extract of Magnolia obovata leaves, and identified as obovatol, honokiol, and magnolol. The active compounds inhibit rat liver ACAT with IC50 values of 42, 71, and 86 mu M, respectively.
引用
收藏
页码：550 / 551
页数：2
相关论文
共 50 条
  • [41] Novel 3,5-diaryl pyrazolines as human acyl-CoA:cholesterol acyltransferase inhibitors
    Jeong, TS
    Kim, KS
    An, SJ
    Cho, KH
    Lee, S
    Lee, WS
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (11) : 2715 - 2717
  • [42] PYRIPYROPENES, HIGHLY POTENT INHIBITORS OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY ASPERGILLUS-FUMIGATUS
    OMURA, S
    TOMODA, H
    KIM, YK
    NISHIDA, H
    JOURNAL OF ANTIBIOTICS, 1993, 46 (07) : 1168 - 1169
  • [43] MOLECULAR MODULATION OF ACYL-COA CHOLESTEROL ACYLTRANSFERASE IN RAT-LIVER
    SMITH, JL
    KWOK, CT
    HARDIE, IR
    PILLAY, SP
    PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 1983, 15 : 63 - 63
  • [44] Total synthesis of acyl-CoA: Cholesterol acyltransferase inhibitor beauveriolide I
    Tian, Hua
    Jiao, Xiao-Zhen
    Xie, Ping
    Liang, Xiao-Tian
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2007, 27 (01) : 103 - 108
  • [45] THE PRESENCE OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE IN TETRAHYMENA-PYRIFORMIS-W
    BILLHEIMER, JT
    LANDREY, JR
    CONNER, RL
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1989, 92 (04): : 675 - 680
  • [46] SUBCELLULAR DISTRIBUTION OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE IN RAT LIVER CELLS
    STOKKE, KT
    NORUM, KR
    BIOCHIMICA ET BIOPHYSICA ACTA, 1970, 210 (01) : 202 - +
  • [47] INTERACTIONS OF A PHOTOSENSITIVE ANALOG OF CHOLESTEROL WITH HYDROXYMETHYLGLUTARYL-COA REDUCTASE (NADPH) AND ACYL-COA - CHOLESTEROL ACYLTRANSFERASE
    HELLER, RA
    KLOTZBUCHER, R
    STOFFEL, W
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (04) : 1721 - 1725
  • [48] N-SUBSTITUTED GLYCINE ANILIDES - A NEW SERIES OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE (ACAT) INHIBITORS
    ROARK, WH
    ROTH, BD
    ESSENBURG, AD
    KRAUSE, BR
    STANFIELD, RL
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1991, 201 : 114 - MEDI
  • [49] ESTERIFICATION OF CHOLESTEROL IN HUMAN SMALL-INTESTINE - IMPORTANCE OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE
    NORUM, KR
    LILLJEQVIST, AC
    HELGERUD, P
    NORMANN, ER
    MO, A
    SELBEKK, B
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1979, 9 (01) : 55 - 62
  • [50] Triterpenoids from the Flower of Campsis grandiflora K. Schum. as Human Acyl-CoA: Cholesterol Acyltransferase Inhibitors
    Dong-Hyun Kim
    Kyung-Min Han
    In-Sik Chung
    Dae-Keun Kim
    Sung-Hoon Kim
    Byoung-Mog Kwon
    Tae-Sook Jeong
    Mi-Hyun Park
    Eun-Mi Ahn
    Nam-In Baek
    Archives of Pharmacal Research, 2005, 28 : 550 - 556
12345