Acyl-CoA: Cholesterol acyltransferase inhibitors from Magnolia obovata

被引：31
|
作者：
Kwon, BM
Kim, MK
Lee, SH
Kim, JA
Lee, IR
Kim, YK
Bok, SH
机构：
[1] KIST, Korea Res Inst Biosci & Biotechnol, Prot Regulatro RU, Taejon 305600, South Korea
[2] Ewha Womans Univ, Coll Pharm, Seoul, South Korea
来源：
PLANTA MEDICA | 1997年 / 63卷 / 06期
关键词：
D O I：
10.1055/s-2006-957762
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
In the course of a search for acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors from natural sources, new types of ACAT inhibitors were isolated from the extract of Magnolia obovata leaves, and identified as obovatol, honokiol, and magnolol. The active compounds inhibit rat liver ACAT with IC50 values of 42, 71, and 86 mu M, respectively.
引用
收藏
页码：550 / 551
页数：2
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