Intestinal micropatches for oral insulin delivery

被引:40
作者
Banerjee, Amrita [1 ]
Wong, Jessica [1 ]
Gogoi, Rohan [2 ]
Brown, Tyler [3 ]
Mitragotri, Samir [1 ,4 ]
机构
[1] Univ Calif Santa Barbara, Dept Chem Engn, Engn 2,Room 3349, Santa Barbara, CA 93106 USA
[2] Univ Calif Santa Barbara, Coll Letters & Sci, Santa Barbara, CA 93106 USA
[3] Univ Calif Santa Barbara, Interdept Program Biomol Sci & Engn, Santa Barbara, CA 93106 USA
[4] Univ Calif Santa Barbara, Ctr Bioengn, Barbara, CA USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
Diabetes; micropatch; oral insulin delivery; permeation enhancer; proteolytic inhibitor; IN-VITRO; DIABETIC-RATS; NANOPARTICLES; MUCUS; MICROSPHERES; SYSTEMS; MACROMOLECULES; CHITOSAN; VIVO; MICROPARTICLES;
D O I
10.1080/1061186X.2017.1300664
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Diabetes mellitus has become a major public health issue that has almost reached epidemic proportions worldwide. Injectable insulin has been typically utilized for the management of this chronic disease. However, lack of patient compliance with injectable formulations has spurred the development of oral insulin formulations, which although appealing, face several delivery challenges. We have developed novel mucoadhesive intestinal patches, several hundred micrometers in dimension (micropatches) that address the challenges of oral insulin delivery. The micropatches adhere to the intestinal mucosa, release their drug load rapidly within 30min and are effective in lowering blood glucose levels in vivo. When insulin-loaded micropatches were administered with a permeation enhancer and protease inhibitor, a peak efficacy of 34% drop in blood glucose levels was observed within 3h. Efficacy further improved to 41% when micropatches were administered in multiple doses. Here, we describe the design of micropatches as an oral insulin formulation and report their in vivo efficacy.
引用
收藏
页码:608 / 615
页数:8
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