Epidemiology of extended-spectrum β-lactamase and metallo-β-lactamase-producing Escherichia coli in South Asia

被引：12

作者：

Islam, Kamrul ^{[1
]}

Heffernan, Aaron J. ^{[1
,2
]}

Naicker, Saiyuri ^{[1
]}

Henderson, Andrew ^{[3
,8
]}

Hassen Chowdhury, Mohammed Abdul ^{[7
]}

Roberts, Jason A. ^{[1
,3
,4
,5
,6
]}

Sime, Fekade B. ^{[1
,3
]}

机构：

[1] Univ Queensland, Sch Pharm, Ctr Translat Antiinfect Pharmacodynam, Brisbane, Qld 4103, Australia

[2] Griffith Univ, Sch Med, Southport, Qld 4215, Australia

[3] Univ Queensland, Ctr Clin Res, Fac Med, Brisbane, Qld 4029, Australia

[4] Royal Brisbane & Womens Hosp, Dept Intens Care Med, Brisbane, Qld 4029, Australia

[5] Royal Brisbane & Womens Hosp, Pharm Dept, Brisbane, Qld 4029, Australia

[6] Univ Montpellier, Nimes Univ Hosp, Div Anaesthesiol Crit Care Emergency & Pain Med, F-30029 Nimes, France

[7] Bangladesh Inst Trop & Infect Dis BITID, Chittagong 4317, Bangladesh

[8] Princess Alexandra Hosp, Infect Management Serv, Brisbane, Qld 4103, Australia

来源：

FUTURE MICROBIOLOGY | 2021年 / 16卷 / 07期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

Escherichia coli; extended-spectrum β -lactamase; meta-analysis; metallo-β prevalence; South Asia; ANTIBIOTIC-RESISTANCE; ENTEROBACTERIACEAE; PREVALENCE; INFECTIONS; HOSPITALS; DISSEMINATION; METAANALYSIS; EMERGENCE; COUNTRY; GENES;

D O I：

10.2217/fmb-2020-0193

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: To determine the prevalence of extended-spectrum beta-lactamase (ESBL) and metallo-beta-lactamase (MBL)-producing Escherichia coli in South Asia. Methodology: A systematic review and meta-analysis of data published in PubMed, EMBASE, Web of Science and Scopus. Results: The pooled prevalence of ESBL and MBL-producing E. coli in South Asia were 33% (95% CI: 27-40%) and 17% (95% CI: 12-24%), respectively. The prevalence of bla(CTX-M) type was 58% (95% CI: 49-66%) with bla(CTX-M-15) being the most prevalent (51%, 95% CI: 40-62%) variant. The most prevalent MBL variant was bla(NDM-1) (33%, 95% CI: 20-50%). Conclusion: This study suggests a high prevalence of ESBLs and MBLs among E. coli clinical isolates. Comprehensive resistance surveillance is required to guide clinicians prescribing antibiotics in South Asia.

引用

页码：521 / 535

页数：15

共 59 条

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