Rituximab Therapy for Childhood Pemphigus Vulgaris

被引：15

作者：

Kincaid, Leah ^{[1
,2
]}

Weinstein, Miriam ^{[1
,2
]}

机构：

[1] Univ Toronto, Dept Med, Div Dermatol, Toronto, ON, Canada

[2] Hosp Sick Children, Div Pediat Med, Dermatol Sect, 555 Univ Ave, Toronto, ON M5G 1X8, Canada

来源：

PEDIATRIC DERMATOLOGY | 2016年 / 33卷 / 02期

关键词：

RESPONSES;

D O I：

10.1111/pde.12744

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Pediatric pemphigus vulgaris (PV) is a rare autoimmune bullous dermatosis that poses a diagnostic and therapeutic challenge. Rituximab, an anti-CD20 monoclonal antibody, is an important medication in adult PV but has rarely been used to treat pediatric disease. We describe successful rituximab therapy in a 4-year-old, the youngest patient with PV ever reported to receive rituximab. A live attenuated vaccination was later given without incident. We also review rituximab clinical outcomes, toxicity, dosing protocols, and relapse in children with PV.

引用

收藏

页码：E61 / E64

页数：4

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