Simvastatin lowers reactive oxygen species level by Nrf2 activation via PI3K/Akt pathway

被引：63

作者：

Chartoumpekis, Dionysios ^{[1
]}

Ziros, Panos G. ^{[1
]}

Psyrogiannis, Agathoklis ^{[1
]}

Kyriazopoulou, Venetsana ^{[1
]}

Papavassiliou, Athanasios G. ^{[2
]}

Habeos, Ioannis G. ^{[1
]}

机构：

[1] Univ Patras, Sch Med, Dept Internal Med, Patras 26500, Greece

[2] Univ Athens, Sch Med, Dept Biol Chem, GR-11527 Athens, Greece

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 396卷 / 02期

关键词：

Nrf2; Simvastatin; Reactive oxygen species; HMG-CoA reductase inhibitors; PI3K/Akt; HEME OXYGENASE-1; OXIDATIVE STRESS; STATINS; CELLS; EXPRESSION; GENES; LIVER; AKT;

D O I：

10.1016/j.bbrc.2010.04.117

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The beneficial effects of HMG-CoA (3-hydroxy-3-methyl-glutaryl-CoA) reductase inhibitors (statins) have been attributed not only to their cholesterol lowering effect but also to their pleiotropic actions and especially to their anti-oxidant activity. Nrf2 (NF-E2-related factor 2) is a transcription factor that orchestrates the transcriptional response of cells to oxidative stressors and electrophilic xenobiotics. In this study, primary mouse embryonic fibroblasts from wild type or Nrf2 knock out C57B16J mice and ST-2 cells were used to investigate the implication of Nrf2 in the mediation of the anti-oxidant effects of statins and the possible involvement of PI3K/Akt pathway in this process. We show for the first time that simvastatin lowers reactive oxygen species (ROS) by activating Nrf2 through the PI3K/Akt pathway. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：463 / 466

页数：4

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