Reactivity of Dinuclear Copper(II) Complexes with N-Salicylidene Glycine Schiff Bases as Carboxylesterase Models

被引：5

作者：

Xu, Bin ^{[1
,2
]}

Jiang, Weidong ^{[1
,2
]}

Liu, Fuan ^{[2
]}

Yu, Yongde ^{[1
]}

Dong, Juan ^{[1
]}

机构：

[1] Sichuan Univ Sci & Engn, Sch Chem & Pharmaceut Engn, Zigong 643000, Sichuan, Peoples R China

[2] Sichuan Inst High Educ, Key Lab Green Catalysis, Sicuan Zigong 643000, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CHEMICAL KINETICS | 2015年 / 47卷 / 03期

基金：

芬兰科学院;

关键词：

PHOSPHATE ESTER HYDROLYSIS; DNA-BINDING; ZINC(II) COMPLEXES; CLEAVAGE; BINUCLEAR; LIGANDS; INHIBITION; CATALYSIS; AGENTS;

D O I：

10.1002/kin.20904

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Two phenoxo-bridged dinuclear copper(II) complexes (Cu2L21, Cu2L22) with N-salicylidene glycine Schiff bases were prepared and evaluated their performance for catalyzing the hydrolysis of p-nitrophenyl picolinate (PNPP). The observations reveal that the as-prepared dinuclear copper(II) complexes exhibited better activity by two to three orders of magnitude rate enhancement in comparison with the autohydrolysis rate of PNPP. Chloro-containing Cu2L22 aroused approximately three times kinetic advantage over chloro-free Cu2L21 at pH 7.0, which is probably contributed to the electron-withdrawing inductive effect of the 5-chloride group. Moreover, it was found that the pH-responded kinetic behavior displayed an enzyme-like property for the PNPP hydrolysis by the two complexes.

引用

页码：191 / 198

页数：8

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