Extending research based on different-sex (i.e., heterosexual) couples, the authors explored associations between romantic relationship quality and depressive symptoms in a geographically diverse sample (N = 571) of U.S. adults in same-sex relationships. The authors also examined whether this association was moderated by individual characteristics (gender, age, and internalized heterosexism) or relationship factors (relationship length, commitment, and interdependence). Results indicated a moderate negative association between relationship quality and depressive symptoms, echoing findings from different-sex couples. This association was not moderated by gender, age, internalized heterosexism, or relationship length. In contrast, commitment and interdependence did demonstrate moderating effects. Although the negative association between relationship quality and depressive symptoms was present at all levels of commitment and interdependence, it was amplified at higher commitment and interdependence levels. In general, findings contribute to a growing literature suggesting many commonalities between same-sex and opposite sex couples. Specifically, they suggest the importance of relationship quality to the emotional well-being of LGBT adults, supporting clinical interventions and social policies that promote healthy and stable same-sex relationships.