The nuclear nurture and cytoplasmic nature of localized mRNPs

被引：98
作者：
Giorgi, Corinna [1 ]
Moore, Melissa J. [1 ]
机构：
[1] Brandeis Univ, Howard Hughes Med Inst, Dept Biochem, Waltham, MA 02454 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2007年 / 18卷 / 02期
关键词：
mRNA localization; exon junction complex; nuclear mRNA processing;
D O I：
10.1016/j.semcdb.2007.01.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
From yeast to mammals, evidence has emerged in recent years highlighting the essential role played by the nuclear "history" of a messenger RNA in determining its cytoplasmic fate. mRNA localization, translation and stability in the cytoplasm are often pre-destined in the nucleus, and directed by the composition and architecture of nuclear assembled mRNA-protein complexes. In this review we focus on nuclear-acquired RNA-binding proteins and complexes that participate in determining the journey of localized mRNAs. (C) 2007 Published by Elsevier Ltd.
引用
收藏
页码：186 / 193
页数：8
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