IL-9: Basic Biology, Signaling Pathways in CD4+T Cells and Implications for Autoimmunity

被引:73
作者
Li, Hongmei [2 ]
Rostami, Abdolmohamad [1 ,2 ]
机构
[1] Thomas Jefferson Univ, Dept Neurol, Philadelphia, PA 19107 USA
[2] Thomas Jefferson Univ, Dept Neurol, Philadelphia, PA 19107 USA
基金
美国国家卫生研究院;
关键词
IL-9; helper Tcells; signaling pathways; autoimmune disease; HYPER-IGE SYNDROME; REGULATORY T-CELLS; ROR-GAMMA-T; ARYL-HYDROCARBON RECEPTOR; CENTRAL-NERVOUS-SYSTEM; TGF-BETA; IFN-GAMMA; INTERLEUKIN-4; RECEPTOR; TYROSINE KINASES; LYMPHOMA-CELLS;
D O I
10.1007/s11481-009-9186-y
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
CD4(+) T cell subsets play an important role in the adaptive immune response in human autoimmune diseases and in animal models of autoimmunity. In recent years, our knowledge of CD4(+) T cell differentiation has increased significantly, and new subsets continue to be recognized. Of significant importance is the recent discovery of Th9 cells, the CD4 + T cell subset that produces Interleukin-9. IL-9 has largely been regarded as a Th2 cytokine; however, it is now known that under specific conditions, Tregs, Th1, Th17 and the Th9 subset of T cells also produce IL-9. The STAT family of proteins plays a major role in the signaling pathways of these CD4(+)T subsets. Biological actions of IL-9 and the STATs signaling pathways in autoimmune diseases are continuing to be clarified. Investigation of IL-9-producing CD4(+)T cells, and elucidation of the mechanisms of IL-9-induced STATs signaling, in concert with other transcription factors, will provide a better understanding of the pathogenesis of various autoimmune diseases.
引用
收藏
页码:198 / 209
页数:12
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