Exosomal HSP70 for Monitoring of Frontotemporal Dementia and Alzheimer's Disease: Clinical and FDG-PET Correlation

被引：18

作者：

Chanteloup, Gaetan ^{[1
,2
]}

Cordonnier, Marine ^{[1
,2
]}

Moreno-Ramos, Teresa ^{[3
,4
]}

Pytel, Vanesa ^{[3
,4
]}

Matias-Guiu, Jorge ^{[3
,4
]}

Gobbo, Jessica ^{[5
]}

Nieves Cabrera-Martin, Maria ^{[6
]}

Gomez-Pinedo, Ulises ^{[3
,4
]}

Garrido, Carmen ^{[1
,2
,5
]}

Matias-Guiu, Jordi A. ^{[3
,4
]}

机构：

[1] INSERM, UMR1231, Labex LipSTIC, Dijon, France

[2] Univ Bourgogne Franche Comte, Dijon, France

[3] Univ Complutense Madrid, Hlth Res Inst San Carlos IdISCC, Hosp Clin San Carlos, Dept Neurol, Prof Martin Lagos S-N, E-28040 Madrid, Spain

[4] Univ Complutense Madrid, Hlth Res Inst San Carlos IdISCC, Hosp Clin San Carlos, Lab Neurobiol, Madrid, Spain

[5] Canc Ctr Georges Francois Leclerc, Dijon, France

[6] Univ Complutense Madrid, Hlth Res Inst San Carlos IdISCC, Hosp Clin San Carlos, Dept Nucl Med, Madrid, Spain

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2019年 / 71卷 / 04期

关键词：

Alzheimer's disease; biomarkers; exosomes; frontotemporal dementia; PET; SYNAPTIC PROTEINS; NEURONAL EXOSOMES; CELL;

D O I：

10.3233/JAD-190545

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We aimed to study the expression of circulating heat-shock protein HSP70 and exosomes in plasma of a cohort of patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD) at different stages. We performed correlations with clinical scales and FDG-PET. HSP70 levels were higher within exosomes than free in plasma. Moderate correlations were found between exosomal HSP70 and CDR, FTLD-CDR, and extension of hypometabolism. Our results suggest modifications in the level of exosomal HSP70 during the course of neurodegeneration, regardless of AD or FTD, and therefore HSP70 could have a potential role in the follow-up of these disorders.

引用

页码：1263 / 1269

页数：7

共 23 条

[1] Depletion of microglia and inhibition of exosome synthesis halt tau propagation [J].

Asai, Hirohide ;

Ikezu, Seiko ;

Tsunoda, Satoshi ;

Medalla, Maria ;

Luebke, Jennifer ;

Haydar, Tank ;

Wolozin, Benjamin ;

Butovsky, Oleg ;

Kuegler, Sebastian ;

Ikezu, Tsuneya .

NATURE NEUROSCIENCE, 2015, 18 (11) :1584-1593

[2]

Boudesco C, 2018, METHODS MOL BIOL, V1709, P371, DOI 10.1007/978-1-4939-7477-1_27

[3] Heat Shock Proteins in Alzheimer's Disease: Role and Targeting [J].

Campanella, Claudia ;

Pace, Andrea ;

Bavisotto, Celeste Caruso ;

Marzullo, Paola ;

Gammazza, Antonella Marino ;

Buscemi, Silvestre ;

Piccionello, Antonio Palumbo .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (09)

[4] Exosomes in cancer theranostic: Diamonds in the rough [J].

Cordonnier, Marine ;

Chanteloup, Gaetan ;

Isambert, Nicolas ;

Seigneuric, Renaud ;

Fumoleau, Pierre ;

Garrido, Carmen ;

Gobbo, Jessica .

CELL ADHESION & MIGRATION, 2017, 11 (02) :151-163

[5] Cell-Produced α-Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival [J].

Emmanouilidou, Evangelia ;

Melachroinou, Katerina ;

Roumeliotis, Theodoros ;

Garbis, Spiros D. ;

Ntzouni, Maria ;

Margaritis, Lukas H. ;

Stefanis, Leonidas ;

Vekrellis, Kostas .

JOURNAL OF NEUROSCIENCE, 2010, 30 (20) :6838-6851

[6] Extracellular vesicles, new actors in the search for biomarkers of dementias [J].

Gamez-Valero, Ana ;

Beyer, Katrin ;

Borras, Francesc E. .

NEUROBIOLOGY OF AGING, 2019, 74 :15-20

[7]

Gobbo J, 2015, JNCI-J NATL CANCER I, V22, P108

[8] Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer's disease [J].

Goetzl, Edward J. ;

Abner, Erin L. ;

Jicha, Gregory A. ;

Kapogiannis, Dimitrios ;

Schwartz, Janice B. .

FASEB JOURNAL, 2018, 32 (02) :888-893

[9] Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease [J].

Goetzl, Edward J. ;

Kapogiannis, Dimitrios ;

Schwartz, Janice B. ;

Lobach, Iryna V. ;

Goetzl, Laura ;

Abner, Erin L. ;

Jicha, Gregory A. ;

Karydas, Anna M. ;

Boxer, Adam ;

Miller, Bruce L. .

FASEB JOURNAL, 2016, 30 (12) :4141-4148

[10] Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease [J].

Goetzl, Edward J. ;

Mustapic, Maja ;

Kapogiannis, Dimitrios ;

Eitan, Erez ;

Lobach, Irina V. ;

Goetzl, Laura ;

Schwartz, Janice B. ;

Miller, Bruce L. .

FASEB JOURNAL, 2016, 30 (11) :3853-3859

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