Physiological and pathophysiological role of magnesium in the cardiovascular system: implications in hypertension

被引:125
作者
Laurant, P
Touyz, RM
机构
[1] Univ Montreal, Clin Res Inst Montreal, MRC, Multidisciplinary Res Grp Hypertens, Montreal, PQ H2W 1R7, Canada
[2] Univ Franche Comte, UFR Med & Pharm, Lab Physiol Pharmacol & Nutr Prevent Expt, F-25030 Besancon, France
关键词
cations; vascular smooth muscle cells; calcium; magnesium deficiency; blood pressure; pre-eclampsia;
D O I
10.1097/00004872-200018090-00003
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Attention is growing for a potential role of magnesium in the pathoetiology of cardiovascular disease, Magnesium modulates mechanical, electrical and structural functions of cardiac and vascular cells, and small changes in extracellular magnesium levels and/or intracellular free magnesium concentration may have significant effects on cardiac excitability and on vascular tone, contractility and reactivity, Thus, magnesium may be important in the physiological regulation of blood pressure whereas alterations in cellular magnesium metabolism could contribute to the pathogenesis of blood pressure elevation, Although most epidemiological and experimental studies support a pathological role for magnesium in the etiology and development of hypertension, data from clinical studies have been less convincing. Furthermore, the therapeutic value of magnesium in the management of essential hypertension is unclear, The present review discusses the molecular, biochemical, physiological and pharmacological roles of magnesium in the regulation of vascular function and blood pressure and introduces novel concepts relating to magnesium as a second messenger in intracellular signaling in cardiovascular cells. In addition, alterations in magnesium regulation in experimental and clinical hypertension and the potential antihypertensive therapeutic effects of magnesium are addressed, I Hypertens 2000, 18:1177-1191 (C) Lippincott Williams & Wilkins.
引用
收藏
页码:1177 / 1191
页数:15
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共 207 条
[61]  
GRYNKIEWICZ G, 1985, J BIOL CHEM, V260, P3440
[62]   ISOPROTERENOL-INDUCED MG-2+ UPTAKE IN LIVER [J].
GUNTHER, T ;
VORMANN, J ;
HOLLRIEGL, V .
FEBS LETTERS, 1992, 307 (03) :333-336
[63]  
HANDWERKER SM, 1995, J REPROD MED, V40, P201
[64]   MAGNESIUM ABSORPTION - MECHANISMS AND THE INFLUENCE OF VITAMIN-D, CALCIUM AND PHOSPHATE [J].
HARDWICK, LL ;
JONES, MR ;
BRAUTBAR, N ;
LEE, DBN .
JOURNAL OF NUTRITION, 1991, 121 (01) :13-23
[65]   Dietary Approaches to Stop Hypertension: A summary of study results [J].
Harsha, DW ;
Lin, PH ;
Obarzanek, E ;
Karanja, NM ;
Moore, TJ ;
Caballero, B .
JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION, 1999, 99 (08) :S35-S39
[66]  
HAUGLAND RP, 1997, HDB FLUORESCENT PROB, P503
[67]   Extracellular calcium-sensing receptor: Implications for calcium and magnesium handling in the kidney [J].
Hebert, SC .
KIDNEY INTERNATIONAL, 1996, 50 (06) :2129-2139
[68]   Abnormal platelet Ca2+ handling accompanied by increased cytosolic free Mg2+ in essential hypertension [J].
Hiraga, H ;
Oshima, T ;
Yoshimura, M ;
Matsuura, H ;
Kajiyama, G .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1998, 275 (02) :R574-R579
[69]   The effects of high oral magnesium supplementation on blood pressure, serum lipids and related variables in apparently healthy Japanese subjects [J].
Itoh, K ;
Kawasaki, T ;
Nakamura, M .
BRITISH JOURNAL OF NUTRITION, 1997, 78 (05) :737-750
[70]   INTRACELLULAR FREE MAGNESIUM AND HIGH-ENERGY PHOSPHATES IN THE PERFUSED NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RAT-HEART - A P-31 NMR-STUDY [J].
JELICKS, LA ;
GUPTA, RK .
AMERICAN JOURNAL OF HYPERTENSION, 1991, 4 (02) :131-136