Oscillations in transcription factor dynamics:: a new way to control gene expression

被引：0

作者：

Nelson, DE ^{[1
]}

Sée, V ^{[1
]}

Nelson, G ^{[1
]}

White, MRH ^{[1
]}

机构：

[1] Univ Liverpool, Sch Biol Sci, Ctr Cell Imaging, Liverpool L69 7ZB, Merseyside, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷

关键词：

gene expression; NF-kappa B; oscillations; transcription;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

oscillations in second-messenger signalling (e.g. calcium) have previously been shown to be important in the control of transcription. More recently, oscillations in localization and absolute levels of transcription factors and their regulators have been identified. Here we discuss the role of network motifs such as the negative feedback loop and their role in oscillatory signalling, and how oscillations in components of the nuclear factor kappaB signalling pathway are important to the dynamic control of transcription in response to a cytokine stimulus.

引用

页码：1090 / 1092

页数：3

共 15 条

[1] The versatility and universality of calcium signalling [J].

Berridge, MJ ;

Lipp, P ;

Bootman, MD .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2000, 1 (01) :11-21

[2] The AM and FM of calcium signalling [J].

Berridge, MJ .

NATURE, 1997, 386 (6627) :759-760

[3] Calcium oscillations increase the efficiency and specificity of gene expression [J].

Dolmetsch, RE ;

Xu, KL ;

Lewis, RS .

NATURE, 1998, 392 (6679) :933-936

[4] Differential activation of transcription factors induced by Ca2+ response amplitude and duration [J].

Dolmetsch, RE ;

Lewis, RS ;

Goodnow, CC ;

Healy, JI .

NATURE, 1997, 386 (6627) :855-858

[5] Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations:: a simple model [J].

Dupont, G ;

Houart, G ;

De Koninck, P .

CELL CALCIUM, 2003, 34 (06) :485-497

[6] NF-κB and rel proteins:: Evolutionarily conserved mediators of immune responses [J].

Ghosh, S ;

May, MJ ;

Kopp, EB .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :225-260

[7] The IκB-NF-κB signaling module:: Temporal control and selective gene activation [J].

Hoffmann, A ;

Levchenko, A ;

Scott, ML ;

Baltimore, D .

SCIENCE, 2002, 298 (5596) :1241-1245

[8] Dynamics of the p53-Mdm2 feedback loop in individual cells [J].

Lahav, G ;

Rosenfeld, N ;

Sigal, A ;

Geva-Zatorsky, N ;

Levine, AJ ;

Elowitz, MB ;

Alon, U .

NATURE GENETICS, 2004, 36 (02) :147-150

[9] Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA [J].

Maeda, M ;

Lu, SJ ;

Shaulsky, G ;

Miyazaki, Y ;

Kuwayama, H ;

Tanaka, Y ;

Kuspa, A ;

Loomis, WF .

SCIENCE, 2004, 304 (5672) :875-878

[10] Structure and function of the feed-forward loop network motif [J].

Mangan, S ;

Alon, U .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (21) :11980-11985

← 1 2 →