A report on the activity and clinical outcomes of renal non-heart beating donor transplantation in the United Kingdom

被引:24
作者
Brook, NR
Waller, JR
Richardson, AC
Bradley, JA
Andrews, PA
Koffman, G
Gok, M
Talbot, D
Nicholson, ML
机构
[1] Univ Leicester, Div Transplant Surg, Leicester, Leics, England
[2] Univ Cambridge, Sch Clin Med, Dept Surg, Cambridge, England
[3] SW Thames Renal Transplantat Unit, Dept Surg, London, England
[4] Freeman Rd Hosp, Renal & Liver Transplant Unit, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England
关键词
allograft survival; delayed graft function; kidney transplantation; non-heart beating donor; primary non-function;
D O I
10.1111/j.1399-0012.2004.00287.x
中图分类号
R61 [外科手术学];
学科分类号
摘要
The use of kidneys from non-heart beating donors (NHBDs) presents a paradox; whilst they provide more organs for transplantation, there is an increased risk of poor graft outcome, particularly in the short term. This study has highlighted the difference in early graft function and late graft survival between NHBD kidneys with short (controlled) and long (uncontrolled) warm ischaemic times. Whilst it would seem that it is preferable to use controlled donors only, their numbers are small. By employing a rational approach to the use of each of these types of kidney, such as structured viability assessment and risk analysis, it may be that the results of uncontrolled NHBD can be improved.
引用
收藏
页码:627 / 633
页数:7
相关论文
共 38 条
[1]   Factors influencing short- and long-term survival of kidneys transplanted from non-heart-beating donors [J].
Alvarez, J ;
del Barrio, R ;
Martin, M ;
Rodriguez, G ;
Blesa, AL ;
Ramos, J ;
Nieto, M ;
Martin-Santos, F .
TRANSPLANTATION PROCEEDINGS, 1997, 29 (08) :3490-3490
[2]  
BLACK D, 1995, J ROY COLL PHYS LOND, V29, P381
[3]  
*BRIT TRANSPL SOC, 1998, STAND ORG TISS TRANS
[4]   Non-heart beating donor kidneys with delayed graft function have superior graft survival compared with conventional heart-beating donor kidneys that develop delayed graft function [J].
Brook, NR ;
White, SA ;
Waller, JR ;
Veitch, PS ;
Nicholson, ML .
AMERICAN JOURNAL OF TRANSPLANTATION, 2003, 3 (05) :614-618
[5]   Nonheart-beating kidney donation: Current practice and future developments [J].
Brook, NR ;
Waller, JR ;
Nicholson, ML .
KIDNEY INTERNATIONAL, 2003, 63 (04) :1516-1529
[6]   Are kidneys from non-heart-beating donors second class organs? [J].
Butterworth, PC ;
Taub, N ;
Doughman, TM ;
Horsburgh, T ;
Veitch, PS ;
Bell, PRF ;
Nicholson, ML .
TRANSPLANTATION PROCEEDINGS, 1997, 29 (08) :3567-3568
[7]   EXPERIENCE WITH LIVER AND KIDNEY ALLOGRAFTS FROM NON-HEART-BEATING DONORS [J].
CASAVILLA, A ;
RAMIREZ, C ;
SHAPIRO, R ;
NGHIEM, D ;
MIRACLE, K ;
BRONSTHER, O ;
RANDHAWA, P ;
BROZNICK, B ;
FUNG, JJ ;
STARZL, T .
TRANSPLANTATION, 1995, 59 (02) :197-203
[8]  
CASTELAO AM, 1993, TRANSPLANT P, V25, P1513
[9]   Transplantation of kidneys from donors whose hearts have stopped beating [J].
Cho, YW ;
Terasaki, PI ;
Cecka, JM ;
Gjertson, DW .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (04) :221-225
[10]  
Daemen JHC, 1996, TRANSPL P, V28, P105