An unprecedented tetracyclic diterpenoid with anti-inflammatory activity from Papiliomyces sp.

被引：2

作者：

Sun, Yan ^{[1
]}

Yuan, Chun-Mao ^{[2
]}

Xu, Shuang-Yu ^{[2
]}

Li, Yunyun ^{[1
]}

Yang, Xing-Bian ^{[3
]}

Wen, Ting-Chi ^{[3
]}

Zhou, Kang ^{[1
]}

机构：

[1] Guizhou Univ, Sch Pharmaceut Sci, Huaxi Ave 2708, Guiyang 550025, Peoples R China

[2] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China

[3] Guizhou Univ, Engn Res Ctr Southwest Biopharmaceut Resources, Minist Educ, Guiyang 550025, Guizhou, Peoples R China

来源：

TETRAHEDRON LETTERS | 2022年 / 93卷

基金：

中国国家自然科学基金;

关键词：

Papiliomyces sp; Secondary metabolites; Diterpenoid; Anti-inflammatory activity; ASSISTED STRUCTURE ELUCIDATION; DISCOVERY;

D O I：

10.1016/j.tetlet.2022.153680

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Papiliomyces sp. was found in 2020, and its secondary metabolites have never been reported. Papililone A (1), a new tetracyclic diterpenoid with an unprecedented 5/5/5/6 ring system, was isolated from Papiliomyces sp. under the guidance of HPLC-MS/MS investigation. This structure was assigned by detailed spectroscopic analysis, calculated electronic circular dichroism, and computer-assisted structure elucidation. Moreover, 1 exhibited moderate inhibitory activity against lipopolysaccharide induced nitric oxide production in RAW264.7 cells with IC50 value of 30.9 +/- 1.52 mM. (C) 2022 Elsevier Ltd. All rights reserved.

引用

页数：4

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