Studies on the structure and controlled release of chitosan/fibroin microsphere inclusion drug

Miscibility of the fibroin, which was soluble in CaCl2-H2O-C2H5OH aqueous solution, mixed with chitosan was investigated, and its microspheres were prepared. The chitosan (CS)/fibroin (FB) microsphere inclusion fenoprofen calcium (CS-FB-FC) was prepared, and its structure was analyzed by FTIR, X-ray and SEM. The results indicated that blend of chitosan, fibroin and fenoprofen calcium in aqueous solution is miscible, and strong interaction caused by intermolecular hydrogen bonding exits in CS-FB-FC. It was indicated that approximately 77% of fenoprofen from the microsphere were released in phosphate-buffered saline(pH = 7. 4) within the initial 6h, and with increasing the glutaraldehyde concentration, the release of fenoprofen decreased.