Cobalt-Catalyzed Selective Synthesis of Isoquinolines Using Picolinamide as a Traceless Directing Group

被引：99

作者：

Kuai, Changsheng ^{[1
]}

Wang, Lianhui ^{[1
]}

Li, Bobin ^{[1
]}

Yang, Zhenhui ^{[1
]}

Cui, Xiuling ^{[1
]}

机构：

[1] Huaqiao Univ, Sch Biomed Sci, Key Lab Xiamen Marine & Gene Drugs, Engn Res Ctr Mol Med,Minist Educ,Key Lab Fujian M, Xiamen 361021, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 08期

关键词：

C-H ACTIVATION; C(SP(3))-H BOND ACTIVATION; HETEROCYCLE SYNTHESIS; IRIDIUM COMPLEXES; CARBOXYLIC-ACIDS; ELECTROCHEMICAL PROPERTIES; BETA-PHENYLETHYLAMINES; FUNCTIONAL MOLECULES; ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS;

D O I：

10.1021/acs.orglett.7b00702

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Picolinamide has first been employed as a traceless directing group for the cobalt-catalyzed oxidative annulation of benzylamides with alkynes to synthesize isoquinolines through C-H/N-H bonds activation. Oxygen is used as a terminal oxidant. This protocol exhibits good functional group tolerance and excellent regioselectivity. Both terminal and internal alkynes can be efficiently applied to this catalytic system as substrates.

引用

页码：2102 / 2105

页数：4

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