Survival in endometrial cancer in relation to minimally invasive surgery or open surgery - a Swedish Gynecologic Cancer Group (SweGCG) study

被引：7

作者：

Borgfeldt, Christer ^{[1
]}

Holmberg, Erik ^{[2
]}

Marcickiewicz, Janusz ^{[3
]}

Stalberg, Karin ^{[4
]}

Tholander, Bengt ^{[5
]}

Lundqvist, Elisabeth Avall ^{[6
,7
]}

Floter-Radestad, Angelique ^{[8
]}

Bjurberg, Maria ^{[9
,10
]}

Dahm-Kahler, Pernilla ^{[11
]}

Hellman, Kristina ^{[12
]}

Hjerpe, Elisabet ^{[13
]}

Kjolhede, Preben ^{[14
]}

Rosenberg, Per ^{[6
,7
]}

Hogberg, Thomas ^{[15
]}

机构：

[1] Lund Univ, Skane Univ Hosp, Dept Obstet & Gynecol, SE-22185 Lund, Sweden

[2] Reg Canc Ctr West, SE-41345 Gothenburg, Region Vastra G, Sweden

[3] Halland Hosp, Dept Obstet & Gynecol, SE-43281 Varberg, Sweden

[4] Uppsala Univ, Dept Womens & Childrens Hlth, SE-75185 Uppsala, Sweden

[5] Uppsala Univ Hosp, Dept Oncol, SE-75185 Uppsala, Sweden

[6] Linkoping Univ, Dept Oncol, SE-58185 Linkoping, Sweden

[7] Linkoping Univ, Dept Biomed & Clin Sci, SE-58185 Linkoping, Sweden

[8] Karolinska Univ Hosp, Karolinska Inst, Div Neonatol Obstet & Gynecol, Dept Womens & Childrens Hlth, SE-17176 Stockholm, Sweden

[9] Lund Univ, Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, SE-22185 Lund, Sweden

[10] Lund Univ, Dept Clin Sci, SE-22185 Lund, Sweden

[11] Sahlgrens Acad, Inst Clin Sci, Dept Obstet & Gynecol, SE-41345 Gothenburg, Sweden

[12] Karolinska Univ Hosp, Theme Canc, Dept Gynecol Canc, SE-17176 Stockholm, Sweden

[13] Visby Hosp, Dept Gynecol & Obstet, SE-62155 Visby, Sweden

[14] Linkoping Univ, Dept Biomed & Clin Sci, Dept Obstet & Gynecol Linkoping, SE-58185 Linkoping, Sweden

[15] Lund Univ, Dept Clin Sci, Dept Med Oncol, SE-22100 Lund, Sweden

来源：

BMC CANCER | 2021年 / 21卷 / 01期

关键词：

Endometrial cancer; Minimally invasive surgery; Survival; Risk factors; HYSTERECTOMY; LAPAROSCOPY; RECURRENCE; LAPAROTOMY; WOMEN;

D O I：

10.1186/s12885-021-08289-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundThe aim of this study was to analyze overall survival in endometrial cancer patients' FIGO stages I-III in relation to surgical approach; minimally invasive (MIS) or open surgery (laparotomy).MethodsA population-based retrospective study of 7275 endometrial cancer patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed from 2010 to 2018. Cox proportional hazard models were used in univariable and multivariable survival analyses.ResultsIn univariable analysis open surgery was associated with worse overall survival compared with MIS hazard ratio, HR, 1.39 (95% CI 1.18-1.63) while in the multivariable analysis, surgical approach (MIS vs open surgery) was not associated with overall survival after adjustment for known risk factors (HR 1.12, 95% CI 0.95-1.32). Higher FIGO stage, non-endometrioid histology, non-diploid tumors, lymphovascular space invasion and increasing age were independent risk factors for overall survival.ConclusionThe minimal invasive or open surgical approach did not show any impact on survival for patients with endometrial cancer stages I-III when known prognostic risk factors were included in the multivariable analyses.

引用

页数：10

共 26 条

[1] Canadian high risk endometrial cancer (CHREC) consortium: Analyzing the clinical behavior of high risk endometrial cancers [J].

Altman, Alon D. ;

Ferguson, Sarah E. ;

Atenafu, Eshetu G. ;

Koebel, Martin ;

McAlpine, Jessica N. ;

Panzarella, Tony ;

Lau, Susie ;

Gien, Lilian T. ;

Gilks, Blake ;

Clarke, Blaise ;

Cameron, Anna ;

Nelson, Gregg ;

Han, Guangming ;

Samouelian, Vanessa ;

Ho, T. C. ;

Louie, Kim ;

Bernardini, Marcus Q. .

GYNECOLOGIC ONCOLOGY, 2015, 139 (02) :268-274

[2] Endometrial cancer [J].

Amant, F ;

Moerman, P ;

Neven, P ;

Timmerman, D ;

Van Limbergen, E ;

Vergote, I .

LANCET, 2005, 366 (9484) :491-505

[3] CYTOPHOTOMETRY [J].

AUER, G ;

ASKENSTEN, U ;

AHRENS, O .

HUMAN PATHOLOGY, 1989, 20 (06) :518-527

[4] STATISTICAL EVALUATION OF CELL KINETIC DATA FROM DNA FLOW-CYTOMETRY (FCM) BY THE EM ALGORITHM [J].

BALDETORP, B ;

DALBERG, M ;

HOLST, U ;

LINDGREN, G .

CYTOMETRY, 1989, 10 (06) :695-705

[5] Minimally invasive hysterectomy surgery rates for endometrial cancer performed at National Comprehensive Cancer Network (NCCN) Centers [J].

Bergstrom, Jennifer ;

Aloisi, Alessia ;

Armbruster, Shannon ;

Yen, Ting-Tai ;

Casarin, Jvan ;

Leitao, Mario M., Jr. ;

Tanner, Edward J. ;

Matsuno, Rayna ;

Machado, Karime Kalil ;

Dowdy, Sean C. ;

Soliman, Pamela T. ;

Wethington, Stephanie L. ;

Stone, Rebecca L. ;

Levinson, Kimberly L. ;

Fader, Amanda N. .

GYNECOLOGIC ONCOLOGY, 2018, 148 (03) :480-484

[6] A population-based registry study evaluating surgery in newly diagnosed uterine cancer [J].

Borgfeldt, Christer ;

Kalapotharakos, Grigorios ;

Asciutto, Katrin C. ;

Lofgren, Mats ;

Hogberg, Thomas .

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2016, 95 (08) :901-911

[7] Substantial lymph-vascular space invasion (LVSI) is a significant risk factor for recurrence in endometrial cancer - A pooled analysis of PORTEC 1 and 2 trials [J].

Bosse, Tjalling ;

Peters, Elke E. M. ;

Creutzberg, Carien L. ;

Jurenliemk-Schulz, Ina M. ;

Jobsen, Jan J. ;

Mens, Jan Willem M. ;

Lutgens, Ludy C. H. W. ;

van der Steen-Banasik, Elzbieta M. ;

Smit, Vincent T. H. B. M. ;

Nout, Remi A. .

EUROPEAN JOURNAL OF CANCER, 2015, 51 (13) :1742-1750

[8] High cardiovascular disease mortality after endometrial cancer diagnosis: Results from the Surveillance, Epidemiology, and End Results (SEER) Database [J].

Felix, Ashley S. ;

Bower, Julie K. ;

Pfeiffer, Ruth M. ;

Raman, Subha V. ;

Cohn, David E. ;

Sherman, Mark E. .

INTERNATIONAL JOURNAL OF CANCER, 2017, 140 (03) :555-564

[9] Laparoscopy versus laparotomy for the management of early stage endometrial cancer [J].

Galaal, Khadra ;

Donkers, Hannah ;

Bryant, Andrew ;

Lopes, Alberto D. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2018, (10)

[10] Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers [J].

Hamilton, CA ;

Cheung, MK ;

Osann, K ;

Chen, L ;

Teng, NN ;

Longacre, TA ;

Powell, MA ;

Hendrickson, MR ;

Kapp, DS ;

Chan, JK .

BRITISH JOURNAL OF CANCER, 2006, 94 (05) :642-646

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