Engineering of Exosomes: Steps Towards Green Production of Drug Delivery System

被引：18
作者：
Sherif, Abdelrahman Y. [1 ,2 ]
Harisa, Gamaleldin, I [1 ,2 ,3 ]
Alanazi, Fars K. [1 ,2 ]
Youssof, Abdullah M. E. [1 ,2 ]
机构：
[1] King Saud Univ, Coll Pharm, Kayyali Chair Pharmaceut Ind, Riyadh, Saudi Arabia
[2] King Saud Univ, Coll Pharm, Dept Pharmaceut, POB 2457, Riyadh 11541, Saudi Arabia
[3] Al Azhar Univ, Dept Biochem, Coll Pharm, Cairo, Egypt
来源：
CURRENT DRUG TARGETS | 2019年 / 20卷 / 15期
关键词：
Drug targeting; biological DDS; green DDS; exosome; bionanocarrier; vesicular carrier; EXTRACELLULAR VESICLES; IN-VITRO; TARGETED DELIVERY; BACTERIAL GHOSTS; DOXORUBICIN; CELLS; PACLITAXEL; BRAIN; NANOPARTICLES; NANOCARRIERS;
D O I：
10.2174/1389450120666190715104100
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Targeting of therapeutic agents to their specific site of action not only increases the treatment efficacy, but also reduces systemic toxicity. Therefore, various drug delivery systems (DDSs) have been developed to achieve this target. However, most of those DDSs have several issues regarding biocompatibility and environmental hazard. In contrast to the synthetic DDSs, exosome-based natural carriers are biocompatible, biodegradable and safe for the environment. Since exosomes play a role in intercellular communication, they have been widely utilized as carriers for different therapeutic agents. This article was aimed to provide an overview of exosomes as an environment-friendly DDS in terms of engineering, isolation, characterization, application and limitation.
引用
收藏
页码：1537 / 1549
页数：13
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