Identification of Differentially Expressed Genes and Lipid Metabolism Signaling Pathways between Muscle and Fat Tissues in Broiler Chickens

被引:11
作者
Zhang, Min [1 ,2 ,3 ]
Zheng, Dan [4 ]
Peng, Zhimei [1 ]
Zhu, Yuting [1 ]
Li, Rongrong [1 ]
Wu, Qiong [1 ,2 ,3 ]
Li, Yan [1 ,2 ,3 ]
Li, Hongyi [1 ,2 ,3 ]
Xu, Weihua [1 ,2 ,3 ]
Zhang, Mao [1 ,2 ,3 ]
Hung, Qichun [1 ,2 ,3 ]
Sun, Yanfa [1 ,2 ,3 ]
机构
[1] Longyan Univ, Coll Life Sci, 1 Dongxiao North Rd, Longyan 364012, Fujian, Peoples R China
[2] Fujian Prov Key Lab Prevent & Control Anim Infect, Longyan 364012, Fujian, Peoples R China
[3] Longyan Univ, Key Lab Prevent Vet Med & Biotechnol, Longyan 364012, Fujian, Peoples R China
[4] Nanjing Normal Univ Taizhou, Taizhou Coll, Taizhou 225300, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
broiler; differentially expressed gene; fat; muscle; lipid metabolism; signaling pathway; INSULIN; OBESITY;
D O I
10.2141/jpsa.0200040
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
In this study, signaling pathways and key differentially expressed genes (DEGs) involved in lipid metabolism in muscle and fat tissues were investigated. Muscle and abdominal fat tissues were obtained from 35-day-old female broilers for RNA sequencing. DEGs between muscle and fat tissues were identified. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of DEGs were performed. A total of 6130 DEGs were identified to be significantly enriched in 365 GO terms, most of which were involved in biological processes, cellular components, and molecular functions in muscle and fat tissues. Three important lipid signaling pathways (pyruvate metabolism, the insulin signaling pathway, and the adipocytokine signaling pathway) were identified among the fat and muscle tissues of broilers. The key common DEGs in these pathways included phosphocnolpyruvate carboxykinase 2 (PCK2), acetyl-CoA carboxylase 1 alpha and beta (ACACA and ACACB), and the mitogen-activated protein kinase (AMPK) gene family. Hence, our findings revealed the pathways and key genes and gene families involved in the regulation of fat deposition in the muscle and fat tissues of broilers.
引用
收藏
页码:131 / 137
页数:7
相关论文
共 50 条
  • [21] Effects of soy-lecithin on lipid metabolism and hepatic expression of lipogenic genes in broiler chickens
    Huang, Jin
    Yang, Dandan
    Gao, Shudong
    Wang, Tian
    [J]. LIVESTOCK SCIENCE, 2008, 118 (1-2) : 53 - 60
  • [22] Effect of early feed restriction on hepatic lipid metabolism and expression of lipogenic genes in broiler chickens
    Yang, Xiaojing
    Zhuang, Junying
    Rao, Kaiqing
    Li, Xiao
    Zhao, Ruqian
    [J]. RESEARCH IN VETERINARY SCIENCE, 2010, 89 (03) : 438 - 444
  • [23] Identification of differentially expressed genes and enriched pathways in lung cancer using bioinformatics analysis
    Long, Tingting
    Liu, Zijing
    Zhou, Xing
    Yu, Shuang
    Tian, Hui
    Bao, Yixi
    [J]. MOLECULAR MEDICINE REPORTS, 2019, 19 (03) : 2029 - 2040
  • [24] Effects of in ovo administration of DHEA on lipid metabolism and hepatic lipogenetic genes expression in broiler chickens during embryonic development
    Zhao, Sumei
    Ma, Haitian
    Zou, Sixiang
    Chen, Weihua
    [J]. LIPIDS, 2007, 42 (08) : 749 - 757
  • [25] Differential regulation of the expression of lipid metabolism-related genes with skeletal muscle type in growing chickens
    Saneyasu, Takaoki
    Kimura, Sayaka
    Kitashiro, Ayana
    Tsuchii, Nami
    Tsuchihashi, Tatsuya
    Inui, Mariko
    Honda, Kazuhisa
    Kamisoyama, Hiroshi
    [J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 2015, 189 : 1 - 5
  • [26] Analysis of differentially expressed genes and signaling pathways involved in atherosclerosis and chronic obstructive pulmonary disease
    Kotlyarov, Stanislav
    [J]. BIOMOLECULAR CONCEPTS, 2022, 13 (01) : 34 - 54
  • [27] Effects of dietary fat source and green tea (Camellia sinensis) extract on genes associated with lipid metabolism and inflammatory responses in female broiler chickens
    Mohammadpour, Fatemeh
    Darmani-kuhi, Hassan
    Mohit, Ardeshir
    Sohani, Mohammad M.
    [J]. ITALIAN JOURNAL OF ANIMAL SCIENCE, 2021, 20 (01) : 578 - 586
  • [28] Identification of differentially expressed genes in omental adipose tissues of obese patients by suppression subtractive hybridization
    Qiu, Jie
    Ni, Yu-Hui
    Gong, Hai-Xia
    Fei, Li
    Pan, Xiao-Qin
    Guo, Mei
    Chen, Rong-Hua
    Guo, Xi-Rong
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 352 (02) : 469 - 478
  • [29] Analysis of Differentially Expressed Genes in Gastrocnemius Muscle between DGAT1 Transgenic Mice and Wild-Type Mice
    Ying, Fei
    Gu, Hao
    Xiong, Yuanzhu
    Zuo, Bo
    [J]. BIOMED RESEARCH INTERNATIONAL, 2017, 2017
  • [30] Effects of Tributyrin Supplementation on Liver Fat Deposition, Lipid Levels and Lipid Metabolism-Related Gene Expression in Broiler Chickens
    Gu, Tiantian
    Duan, Mingcai
    Liu, Jinyu
    Chen, Li
    Tian, Yong
    Xu, Wenwu
    Zeng, Tao
    Lu, Lizhi
    [J]. GENES, 2022, 13 (12)