Aspergoterpenins A-D: Four New Antimicrobial Bisabolane Sesquiterpenoid Derivatives from an Endophytic Fungus Aspergillus versicolor

被引：28

作者：

Guo, Zhi-Yong ^{[1
,2
]}

Tan, Ming-Hui ^{[1
]}

Liu, Cheng-Xiong ^{[1
]}

Lv, Meng-Meng ^{[1
]}

Deng, Zhang-Shuang ^{[1
,2
]}

Cao, Fei ^{[3
]}

Zou, Kun ^{[1
]}

Proksch, Peter ^{[4
]}

机构：

[1] China Three Gorges Univ, Hubei Key Lab Nat Prod Res & Dev, Coll Biol & Pharmaceut Sci, Yichang 443002, Peoples R China

[2] China Three Gorges Univ, Hubei Engn Res Ctr Three Gorges Reg Plant Breedin, Yichang 443002, Peoples R China

[3] Hebei Univ, Key Lab Pharmaceut Qual Control Hebei Prov, Key Lab Med Chem & Mol Diagnost, Coll Pharmaceut Sci,Educ Minist China, Baoding 071002, Peoples R China

[4] Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1, D-40225 Dusseldorf, Germany

来源：

MOLECULES | 2018年 / 23卷 / 06期

关键词：

bisabolanese squiterpenoid; endophytic fungus; Aspergillus versicolor; structural elucidation; antimicrobial activities; SYDONIC ACID; METABOLITES; IDENTIFICATION;

D O I：

10.3390/molecules23061291

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aspergoterpenins A-D (1-4), four new bisabolane sesquiterpenoid derivatives, were obtained from the endophytic fungus, Aspergillus versicolor, together with eight known compounds (5-12), and their structures were elucidated by a comprehensive analysis of their NMR (Nuclear Magnetic Resonance), MS (Mass Spectrum) and CD (Circular Dichroism) spectra. Aspergoterpenin A (1) was the first example with a characteristic ketal bridged-ring part in the degraded natural bisabolane-type sesquiterpene structures. The compounds 1-12 displayed no significant activities against four cancer cell lines (A549, Caski, HepG2 and MCF-7). Further, the antimicrobial activities to Erwinia carotovora sub sp. Carotovora were evaluated, and the results showed that compounds 1-12 displayed antimicrobial activities with MIC values ranging from 15.2 to 85.2 mu g/mL.

引用

页数：10