The protective effects of Sauropus spatulifolius on acute lung injury induced by lipopolysaccharide

BACKGROUND: Sauropus spatulifolius Beille (named 'Long-Li-Ye' in China) is used to make 'herbal tea' to prevent pneumonia. This study aimed to evaluate the antioxidant activities in vitro and the protective effects of Long-Li-Ye on acute lung injury (ALI) induced by lipopolysaccharide (LPS). RESULTS: The supernatant after ethanol addition to Long-Li-Ye water extract (LLYCSL) and the resin eluting fraction of LLYCSL (LLY40) showed strong antioxidant activities in vitro. LLYCSL and LLY40 could attenuate ALI via decreasing myeloperoxidase activity, increasing superoxide dismutase activity and decreasing the levels of tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta(IL-1 beta) and IL-6. In addition, LLY40 could increase catalase activity, increase the levels of IL-10, IL-4 and IL-13 and decrease the TNF-alpha/IL-10 ratio. CONCLUSION: Long-Li-Ye could be used as a natural antioxidant for food production and functional food or dietary supplementation for people with ALI. (C) 2018 Society of Chemical Industry