The protective effects of Sauropus spatulifolius on acute lung injury induced by lipopolysaccharide

被引：21

作者：

Wei, Xiaochen ^{[1
]}

Li, Yanmei ^{[1
]}

Min, Chunyan ^{[2
]}

Lu, Hui ^{[2
]}

Li, Qirun ^{[1
]}

Yuan, Jie ^{[3
]}

Chen, Chen ^{[1
]}

Li, Heran ^{[1
]}

Zhang, Jian ^{[1
]}

Lia, Meng ^{[1
]}

机构：

[1] Soochow Univ, Coll Pharmaceut Sci, Suzhou, Peoples R China

[2] Suzhou Inst Drug Control, Suzhou, Peoples R China

[3] Anhui Inst Food & Drug Control, Hefei, Anhui, Peoples R China

来源：

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE | 2018年 / 98卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Sauropus spatulifolius Beille; antioxidant activities; acute lung injury; lipopolysaccharide; NF-KAPPA-B; ANTIOXIDANT ACTIVITY; CONSTITUENTS; ATTENUATION; SUPEROXIDE; PHENOLICS; COX-2; FOODS; MICE;

D O I：

10.1002/jsfa.8964

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

BACKGROUND: Sauropus spatulifolius Beille (named 'Long-Li-Ye' in China) is used to make 'herbal tea' to prevent pneumonia. This study aimed to evaluate the antioxidant activities in vitro and the protective effects of Long-Li-Ye on acute lung injury (ALI) induced by lipopolysaccharide (LPS). RESULTS: The supernatant after ethanol addition to Long-Li-Ye water extract (LLYCSL) and the resin eluting fraction of LLYCSL (LLY40) showed strong antioxidant activities in vitro. LLYCSL and LLY40 could attenuate ALI via decreasing myeloperoxidase activity, increasing superoxide dismutase activity and decreasing the levels of tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta(IL-1 beta) and IL-6. In addition, LLY40 could increase catalase activity, increase the levels of IL-10, IL-4 and IL-13 and decrease the TNF-alpha/IL-10 ratio. CONCLUSION: Long-Li-Ye could be used as a natural antioxidant for food production and functional food or dietary supplementation for people with ALI. (C) 2018 Society of Chemical Industry

引用

页码：4420 / 4426

页数：7

共 24 条

[1] Determination of antioxidant activity of wine byproducts and its correlation with polyphenolic content [J].

Alonso, AM ;

Guillén, DA ;

Barroso, CG ;

Puertas, B ;

García, A .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2002, 50 (21) :5832-5836

[2]

Bondet V, 1997, FOOD SCI TECHNOL-LEB, V30, P609

[3] Suppression of MAPK and NF-κB Pathways by Limonene Contributes to Attenuation of Lipopolysaccharide-Induced Inflammatory Responses in Acute Lung Injury [J].

Chi, Gefu ;

Wei, Miaomiao ;

Xie, Xianxing ;

Soromou, L. W. ;

Liu, Fang ;

Zhao, Shuhua .

INFLAMMATION, 2013, 36 (02) :501-511

[4] Oxidative stress and acute lung injury [J].

Chow, CW ;

Abreu, MTH ;

Suzuki, T ;

Downey, GP .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2003, 29 (04) :427-431

[5] Eupatorium lindleyanum DC. flavonoids fraction attenuates lipopolysaccharide-induced acute lung injury in mice [J].

Chu, Chunjun ;

Yao, Shi ;

Chen, Jinglei ;

Wei, Xiaochen ;

Xia, Long ;

Chen, Daofeng ;

Zhang, Jian .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2016, 39 :23-33

[6]

Editorial Committee of Chinese Materia Medica State Administration of Traditional Chinese Medicine, 1999, CHINESE MAT MED

[7] Anti-inflammatory effect of SQC-β-CD on lipopolysaccharide-induced acute lung injury [J].

Feng, Qin ;

Ren, Yong ;

Wang, Yu ;

Ma, Hsiaoyen ;

Xu, Jun ;

Zhou, Chenrong ;

Yin, Zhimin ;

Luo, Lan .

JOURNAL OF ETHNOPHARMACOLOGY, 2008, 118 (01) :51-58

[8] Phenolic compounds, antioxidant potential and antiproliferative potential of 10 common edible flowers from China assessed using a simulated in vitro digestion-dialysis process combined with cellular assays [J].

Huang, Weisu ;

Mao, Shuqin ;

Zhang, Liuquan ;

Lu, Baiyi ;

Zheng, Lufei ;

Zhou, Fei ;

Zhao, Yajing ;

Li, Maiquan .

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2017, 97 (14) :4760-4769

[9] Using 99mTc-DTPA radioaerosol inhalation lung scintigraphies to detect the lung injury induced by consuming Sauropus androgynus vegetable and comparison with conventional pulmonary function tests [J].

Kao, CH ;

Ho, YJ ;

Wu, CL ;

ChangLai, SP .

RESPIRATION, 1999, 66 (01) :46-51

[10] [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin [J].

Kim, SO ;

Kundu, JK ;

Shin, YK ;

Park, JH ;

Cho, MH ;

Kim, TY ;

Surh, YJ .

ONCOGENE, 2005, 24 (15) :2558-2567

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