Visible light-induced nitric oxide release from a novel nitrobenzene derivative cross-conjugated with a coumarin fluorophore

被引：22

作者：

Kitamura, Kai ^{[1
]}

Ieda, Naoya ^{[1
]}

Hishikawa, Kazuhiro ^{[1
]}

Suzuki, Takayoshi ^{[2
]}

Miyata, Naoki ^{[1
]}

Fukuhara, Kiyoshi ^{[3
]}

Nakagawa, Hidehiko ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

[2] Kyoto Prefectural Univ Med, Kita Ku, Kyoto 4038334, Japan

[3] Showa Univ, Sch Pharm, Shinagawa Ku, Tokyo 1428555, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 24期

基金：

日本科学技术振兴机构;

关键词：

Nitric oxide; NO donor; Visible light-control; Caged compound; Cross-conjugation; PHOTOLABILE PROTECTING GROUPS;

D O I：

10.1016/j.bmcl.2014.10.075

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nitric oxide (NO) is a well-known free-radical molecule which is endogenously biosynthesised and shows various functions in mammals. To investigate NO functions, photocontrollable NO donors, compounds which release NO in response to light, are expected to be potentially useful. However, most of the conventional NO donors require harmful ultra-violet light for NO release. In this study, two dimethylnitrobenzene derivatives conjugated with coumarins were designed, synthesized and evaluated as photocontrollable NO donors. The optical properties and efficiency of photo-induced NO release were dependent upon the nature of the conjugation system. One of these compounds, Bhc-DNB (1), showed spatiotemporally well-controlled NO release in cultured cells upon exposure to light in the less-cytotoxic visible wavelength range (400-430 nm). (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：5660 / 5662

页数：3

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