Rhodium-catalyzed C-H activation/annulation of amidines with 4-diazoisochroman-3-imines toward isochromeno[3,4-c]isoquinolines

被引：22

作者：

Xu, Shengbo ^{[1
,2
]}

Qiao, Shanshan ^{[1
,2
]}

Sun, Song ^{[1
,2
]}

Yu, Jin-Tao ^{[1
,2
]}

Cheng, Jiang ^{[1
,2
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Gehu Rd 1, Changzhou 213164, Peoples R China

[2] Changzhou Univ, Jiangsu Prov Key Lab Fine Petrochem Engn, Gehu Rd 1, Changzhou 213164, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 36期

基金：

中国国家自然科学基金;

关键词：

ISOQUINOLINE ALKALOIDS; FACILE SYNTHESIS; TANDEM REACTIONS; ARYL CHLORIDES; BOND; 1-AMINOISOQUINOLINES; FUNCTIONALIZATION; 2-ALKYNYLBENZALDOXIME; ACTIVATION; LIGANDS;

D O I：

10.1039/c9ob01612k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rhodium-catalyzed C-H activation/annulation of amidines with 4-diazoisochroman-3-imines has been established to afford a series of 8-amino-5H-isochromeno[3,4-c]isoquinolines in moderate to good yields with good functional group tolerance. This reaction proceeded in a sequential C-H activation/carbene migration insertion/intramolecular annulation procedure and featured the construction of a C-C and C-N bond in one pot. UV-vis and fluorescence spectral analyses of these highly fused heteroarenes were performed.

引用

页码：8417 / 8424

页数：8

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