Dietary calcium supplementation to lower blood lead levels in pregnancy and lactation

被引:61
作者
Ettinger, Adrienne S. [1 ]
Hu, Howard
Hernandez-Avila, Mauricio
机构
[1] Harvard Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Channing Lab,Dept Med, Boston, MA USA
[3] Natl Publ Hlth Inst, Inst Nacl Salud Publ, Cuernavaca 62508, Morelos, Mexico
关键词
calcium; diet; supplementation; lead; pregnancy; lactation; review;
D O I
10.1016/j.jnutbio.2006.12.007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pregnancy and lactation are states known to be accompanied by physiologically upregulated bone resorption in response to the calcium demands of the developing fetus and nursing infant. The role of calcium supplements in altering maternal responses to fetal demand for calcium is not fully understood. Exposure to the toxicant lead is known to pose a major hazard to fetal neurodevelopment and growth. Since > 95% of maternal lead is stored in the bone, mobilization of cumulative maternal lead stores into the circulation represents an endogenous source of exposure, which may pose a significant hazard for the fetus and infant. Maternal dietary calcium supplementation has been associated with reductions in lead levels in both animal and human studies when administered during pregnancy and lactation. Therefore, supplementation of the maternal diet with calcium may represent an important secondary prevention strategy aimed not only at reducing circulating levels of lead in the mother but also at reducing lead exposure to the developing fetus and nursing infant. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:172 / 178
页数:7
相关论文
共 60 条
[1]   Pb2+ promotes lipid oxidation and alterations in membrane physical properties [J].
Adonaylo, VN ;
Oteiza, PI .
TOXICOLOGY, 1999, 132 (01) :19-32
[2]  
Albalak R, 2003, ARCH ENVIRON HEALTH, V58, P172
[3]   Blood lead levels and risk factors for lead poisoning among children in Jakarta, Indonesia [J].
Albalak, R ;
Noonan, G ;
Buchanan, S ;
Flanders, WD ;
Gotway-Crawford, C ;
Kim, D ;
Jones, RL ;
Sulaiman, R ;
Blumenthal, W ;
Tan, R ;
Curtis, G ;
McGeehin, MA .
SCIENCE OF THE TOTAL ENVIRONMENT, 2003, 301 (1-3) :75-85
[4]  
Anonymous, 2005, Morbidity and Mortality Weekly Report, V54, P513
[5]  
[Anonymous], 1997, DIET REF INT CALC PH
[6]  
Ballew C, 2001, NUTR REV, V59, P71
[7]  
BARRY PSI, 1970, BRIT J IND MED, V27, P339
[8]  
BARRY PSI, 1975, BRIT J IND MED, V32, P119
[9]   ENVIRONMENTAL-HEALTH HAZARDS - HOW CHILDREN ARE DIFFERENT FROM ADULTS [J].
BEARER, CF .
FUTURE OF CHILDREN, 1995, 5 (02) :11-26
[10]   Ampacity of diversely loaded cables in covered and uncovered trays [J].
Black, WZ ;
Harshe, BL .
IEEE TRANSACTIONS ON POWER DELIVERY, 2000, 15 (01) :3-7