Novel flavivirus or new lineage of West Nile Virus, central Europe

被引：178
作者：
Bakonyi, T
Hubálek, Z
Rudolf, I
Nowotny, N [1 ]
机构：
[1] Univ Vet Med, Zoonoses & Emerging Infect Grp, Clin Dept Diagnost Imaging, A-1210 Vienna, Austria
[2] Szent Istvan Univ, Budapest, Hungary
[3] ASCR, Inst Vertebrate Biol, Brno, Czech Republic
[4] United Arab Emirates Univ, Al Ain, U Arab Emirates
来源：
EMERGING INFECTIOUS DISEASES | 2005年 / 11卷 / 02期
关键词：
D O I：
10.3201/eid1102.041028
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A flavivirus (strain 97-103) was isolated from Culex pipens mosquitoes in 1997 following floods in South Moravia, Czech Republic. The strain exhibited close antigenic relationship to West Nile virus (WNV) prototype strain Eg-101 in a cross-neutralization test. In this study, mouse pathogenicity characteristics and the complete nucleotide and putative amino acid sequences of isolate 97-103, named Rabensburg virus (RabV) after a nearby Austrian city, were determined. RabV shares only 75%-77% nucleotide identity and 89%-90% amino acid identity with representative strains of WNV lineages 1 and 2. Another RabV strain (99-222) was isolated in the same location 2 years later; it showed >99% nucleotide identity to strain 97-103. Phylogenetic analyses of RabV, WNV strains, and other members of the Japanese encephalitis virus (JEV) complex clearly demonstrated that RabV is either a new (third) lineage of WNV or a novel flavivirus of the JEV group.
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页码：225 / 231
页数：7
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