Neuropsychiatric Symptoms Underlying Caregiver Stress and Insight in Alzheimer's Disease

被引：54

作者：

Rocca, Paola ^{[1
]}

Leotta, Daniela ^{[2
]}

Liffredo, Cesare ^{[3
]}

Mingrone, Cinzia ^{[1
]}

Sigaudo, Monica ^{[1
]}

Capellero, Barbara ^{[2
]}

Rocca, Giuseppe ^{[1
]}

Simoncini, Mara ^{[4
]}

Pirfo, Elvezio ^{[3
]}

Bogetto, Filippo ^{[1
]}

机构：

[1] Univ Turin, Psychiat Sect, Dept Neurosci, IT-10126 Turin, Italy

[2] Azienda Sanit Locale TO1, Neurol Unit, Dept Med, Turin, Italy

[3] Azienda Sanit Locale TO2, Dept Mental Hlth, Turin, Italy

[4] Azienda Sanit Locale TO2, Dept Long Term Attendance & Elderly, Geriatr Unit, Turin, Italy

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2010年 / 30卷 / 01期

关键词：

Cluster analysis; Alzheimer's disease; Behavioral and psychological symptoms of dementia; Caregiver burden; PSYCHOLOGICAL SYMPTOMS; OLDER-ADULTS; DEMENTIA; BURDEN; SUBGROUPS; INVENTORY; COGNITION; VALIDITY; IMPACT; CARE;

D O I：

10.1159/000315513

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objective: Cluster analysis based on Alzheimer's disease (AD) neuropsychiatric profile demonstrated validity on care-giver burden, nursing-home placement and survival. The aims of our study were to explore the validity of this approach on caregiver burden, lack of insight and cognitive impairment and to examine the impact of neuropsychiatric profiles on these variables. Method: A data-driven approach (two-step cluster analysis) identified groups of patients based on similarities of their neuropsychiatric symptom profile, as assessed by the Neuropsychiatric Inventory (NPI). ANOVAs and chi(2) tests were used to compare groups with regard to continuous and categorical variables. Linear regressions tested the relationships between NPI and clinical variables. Results: Psychotic/behavioral, depressive and minimally symptomatic clusters differed for caregiver burden and lack of insight. Patients in the minimally symptomatic cluster showed better insight than those in the depressive cluster. Caregivers of the psychotic/behavioral cluster experienced the highest burden. We found positive relationships between NPI and lack of insight in the depressive and minimally symptomatic clusters and between NPI and caregiver burden in all three clusters. Caregiver burden was influenced by the type of symptoms. Conclusions: The cluster analysis was valid for lack of insight and caregiver burden. Symptoms predominant on caregiver burden could become targets for therapy. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：57 / 63

页数：7

共 40 条

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