Bioenergetics and Reactive Nitrogen Species in Bacteria

被引：9
作者：
Borisov, Vitaliy B. [1 ]
Forte, Elena [2 ]
机构：
[1] Lomonosov Moscow State Univ, Belozersky Inst Phys Chem Biol, Leninskie Gory, Moscow 119991, Russia
[2] Sapienza Univ Rome, Dept Biochem Sci, I-00185 Rome, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 13期
基金：
俄罗斯科学基金会;
关键词：
bacterial pathogen; host defense; infectious diseases; human health; molecular bioenergetics; electron transport chain; terminal oxidase; cytochrome oxidase; membrane protein; CYTOCHROME-C-OXIDASE; COPPER OXYGEN REDUCTASES; TERMINAL RESPIRATORY OXIDASES; BD PROTECTS BACTERIA; NITRIC-OXIDE; ESCHERICHIA-COLI; HEME-COPPER; QUINOL OXIDASE; MYCOBACTERIUM-TUBERCULOSIS; DI-HEME;
D O I：
10.3390/ijms23137321
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The production of reactive nitrogen species (RNS) by the innate immune system is part of the host's defense against invading pathogenic bacteria. In this review, we summarize recent studies on the molecular basis of the effects of nitric oxide and peroxynitrite on microbial respiration and energy conservation. We discuss possible molecular mechanisms underlying RNS resistance in bacteria mediated by unique respiratory oxygen reductases, the mycobacterial bcc-aa(3) supercomplex, and bd-type cytochromes. A complete picture of the impact of RNS on microbial bioenergetics is not yet available. However, this research area is developing very rapidly, and the knowledge gained should help us develop new methods of treating infectious diseases.
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页数：22
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