Long-term effect of low-dose imatinib therapy for pulmonary hypertension due to chronic degenerative mitral valve disease in six dogs

被引：0
作者：
Leong, Zi Ping [1 ,2 ]
Arita, Shinji [3 ]
Hikasa, Yoshiaki [1 ,2 ]
机构：
[1] Yamaguchi Univ, United Grad Sch Vet Sci, 1677-1 Yoshida, Yamaguchi 7538515, Japan
[2] Tottori Univ, Fac Agr, Joint Dept Vet Med, Lab Vet Internal Med, 4-101 Koyama Minami, Tottori 6808553, Japan
[3] Arita Sougo Anim Hosp, 1-14-6 Nishi, Higashihiroshima, Hiroshima 7390147, Japan
来源：
THAI JOURNAL OF VETERINARY MEDICINE | 2018年 / 48卷 / 03期
基金：
日本学术振兴会;
关键词：
chronic degenerative mitral valve disease; low-dose imatinib; pulmonary hypertension; ADD-ON THERAPY; ARTERIAL-HYPERTENSION; TYROSINE KINASES; EFFICACY; MESYLATE; REVERSAL;
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Six dogs were diagnosed with pulmonary hypertension (PH) secondary to chronic degenerative mitral valve disease (CDMVD) on echocardiography. Imatinib (3 mg/kg, every 24 hours, PO) was initiated without any changes to the background therapy to treat the PH. Follow-up evaluations at 1, 3, 5 and 6 months revealed substantial clinical and hemodynamic improvements. One dog showed deterioration after the imatinib withdrawal to necessitate a restart therapy. No side effects were observed throughout the 6-month treatment course. Low-dose imatinib may provide a promising treatment alternative for CDMVD-associated PH in dogs.
引用
收藏
页码：499 / 505
页数：7
相关论文
共 18 条
  • [1] Arita S, 2013, CAN VET J, V54, P255
  • [2] Dysregulation of tyrosine kinases and use of imatinib in small animal practice
    Bonkobara, Makoto
    [J]. VETERINARY JOURNAL, 2015, 205 (02) : 180 - 188
  • [3] Long-term safety and efficacy of imatinib in pulmonary arterial hypertension
    Frost, Adaani E.
    Barst, Robyn J.
    Hoeper, Marius M.
    Chang, Hyuk-Jae
    Frantz, Robert P.
    Fukumoto, Yoshihiro
    Galie, Nazzareno
    Hassoun, Paul M.
    Klose, Hans
    Matsubara, Hiromi
    Morrell, Nicholas W.
    Peacock, Andrew J.
    Pfeifer, Michael
    Simonneau, Gerald
    Tapson, Victor F.
    Torres, Fernando
    Vizza, Carmine Dario
    Lawrence, David
    Yang, Wei
    Felser, James M.
    Quinn, Deborah A.
    Ghofrani, Hossein-Ardeschir
    [J]. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2015, 34 (11) : 1366 - 1375
  • [4] Imatinib for the treatment of pulmonary arterial hypertension
    Ghofrani, HA
    Seeger, W
    Grimminger, F
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (13) : 1412 - 1413
  • [5] Imatinib in Pulmonary Arterial Hypertension Patients with Inadequate Response to Established Therapy
    Ghofrani, Hossein A.
    Morrell, Nicholas W.
    Hoeper, Marius M.
    Olschewski, Horst
    Peacock, Andrew J.
    Barst, Robyn J.
    Shapiro, Shelley
    Golpon, Heiko
    Toshner, Mark
    Grimminger, Friedrich
    Pascoe, Steve
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 182 (09) : 1171 - 1177
  • [6] Imatinib Mesylate Has The Potential to Exert Its Efficacy by Down-Regulating The Plasma Concentration of Platelet-Derived Growth Factor in Patients With Pulmonary Arterial Hypertension
    Hatano, Masaru
    Yao, Atsushi
    Shiga, Taro
    Kinugawa, Koichiro
    Hirata, Yasunobu
    Nagai, Ryozo
    [J]. INTERNATIONAL HEART JOURNAL, 2010, 51 (04) : 272 - 276
  • [7] Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease
    Hezzell, Melanie J.
    Boswood, Adrian
    Moonarmart, Walasinee
    Elliott, Jonathan
    [J]. JOURNAL OF VETERINARY CARDIOLOGY, 2012, 14 (01) : 269 - 279
  • [8] Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension Results of the Randomized IMPRES Study
    Hoeper, Marius M.
    Barst, Robyn J.
    Bourge, Robert C.
    Feldman, Jeremy
    Frost, Adaani E.
    Galie, Nazzareno
    Angel Gomez-Sanchez, Miguel
    Grimminger, Friedrich
    Gruenig, Ekkehard
    Hassoun, Paul M.
    Morrell, Nicholas W.
    Peacock, Andrew J.
    Satoh, Toru
    Simonneau, Gerald
    Tapson, Victor F.
    Torres, Fernando
    Lawrence, David
    Quinn, Deborah A.
    Ghofrani, Hossein-Ardeschir
    [J]. CIRCULATION, 2013, 127 (10) : 1128 - +
  • [9] Regulation of MAPKs by growth factors and receptor tyrosine kinases
    Katz, Menachem
    Amit, Ido
    Yarden, Yosef
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2007, 1773 (08): : 1161 - 1176
  • [10] Pulmonary hypertension in canine degenerative mitral valve disease
    Kellihan, Heidi B.
    Stepien, Rebecca L.
    [J]. JOURNAL OF VETERINARY CARDIOLOGY, 2012, 14 (01) : 149 - 164
12