N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action

被引：41

作者：

Lagoja, IM

Pannecouque, C

Van Aerschot, A

Witvrouw, M

Debyser, Z

Balzarini, J

Herdewijn, P

De Clercq, E

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, Med Chem Lab, B-3000 Louvain, Belgium

[2] Katholieke Univ Leuven, Rega Inst Med Res, Lab Virol & Chemotherapy, B-3000 Louvain, Belgium

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 46卷 / 08期

关键词：

D O I：

10.1021/jm0211117

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a series of N-aminoimidazoles (NAIMs) with an uncommon spectrum of antiretroviral activity is described. From a group of 60 closely related molecules, we were able to subdivide the molecules in different groups based on their anti-HIV and anti-SIV activity in vitro (i) molecules acting on a new, immediate postintegration step, (ii) molecules acting on both postintegration and HIV-1 reverse transcriptase (RT) as NNRTI, and (iii) molecules that mainly act at the HIV-1 RT according to an NNRTI-type mode of action.

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页码：1546 / 1553

页数：8

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