Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives

被引：15
作者：
Kheder, Nabila Abdelshafy [1 ,2 ]
机构：
[1] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt
[2] King Khalid Univ, Dept Pharmaceut Chem, Fac Pharm, Abha, Saudi Arabia
来源：
MOLECULES | 2016年 / 21卷 / 03期
关键词：
bis-pyrrole; antibacterial activity; antifungal activity; hydrazonoyl halides; molecular docking; ANTIMICROBIAL EVALUATION; CONVENIENT SYNTHESIS; THIOPHENE; THIAZOLE; PYRAZOLE; FACILE; 1,3,4-THIADIAZOLE; PYRIDINE;
D O I：
10.3390/molecules21030326
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A convenient synthesis of some novel bis-pyrrole derivatives via hydrazonoyl halides is described. Antimicrobial evaluation of some selected examples of the synthesized products was carried out. The bis-pyrrole derivative having chloro substituents showed good activity against all of the used microbes. The molecular docking of the bis-pyrrole derivatives was performed by the Molecular Operating Environment (MOE) program.
引用
收藏
页数：9
相关论文
共 32 条
  • [31] Docking and hydropathic scoring of polysubstituted pyrrole compounds with antitubulin activity
    Tripathi, Ashutosh
    Fornabaio, Micaela
    Kellogg, Glen E.
    Gupton, John T.
    Gewirtz, David A.
    Yeudall, W. Andrew
    Vega, Nina E.
    Mooberry, Susan L.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (05) : 2235 - 2242
  • [32] Diethyl (Z,Z)-3,3′-(ethane-1,2-diyldiimino)dibut-2-enoate
    Zhang, ZF
    Jin, S
    Shang, ZB
    Huang, SP
    Liu, B
    Guo, JP
    [J]. ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 2004, 60 : O176 - O177
1234